Test Your Knowledge on Variability and Classification of Hepatitis C Virus
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Questions and Answers

Which type of viruses are generally more genetically stable than RNA viruses?

  • Paramyxoviruses
  • Retroviruses
  • DNA viruses (correct)
  • RNA viruses
  • What is the term used to describe the presence of genetically different viral variants in the same infected individual?

  • Quasi-species (correct)
  • Re-assortment
  • Selective advantage
  • Genetic drift
  • Which viral replicative enzyme is the most error-prone?

  • DNA polymerase of DNA viruses
  • DNA polymerase of retroviruses
  • RNA polymerase of paramyxoviruses
  • Reverse transcriptase of HBV and retroviruses (correct)
  • Which enzyme in HCV replication contributes to the high degree of variability in the virus?

    <p>Reverse transcriptase</p> Signup and view all the answers

    Which HCV genotype is the most prevalent worldwide and in Europe?

    <p>Genotype 1</p> Signup and view all the answers

    What is the most important baseline predictor for response to Peg-IFN + Ribavirin Combination Therapy for HCV?

    <p>HCV genotype</p> Signup and view all the answers

    What is the most prone to variation among HIV genome regions?

    <p>Env gene</p> Signup and view all the answers

    Which virus has the smallest genome of known animal DNA viruses?

    <p>HBV</p> Signup and view all the answers

    What is the mutation rate of Reverse Transcriptase in HBV genome?

    <p>1 mutation / 105 nucleotide</p> Signup and view all the answers

    Which type of inhibitors target the fusion process of the virus?

    <p>Fusion inhibitors</p> Signup and view all the answers

    What is the pattern of lamivudine resistance mutations that strongly reduces the binding affinity with neutralizing antibodies?

    <p>I195M+E164D in the HBsAg</p> Signup and view all the answers

    Which viruses are subject to antigenic drift?

    <p>Influenza virus, HIV, HBV, and HCV</p> Signup and view all the answers

    What is antigenic shift?

    <p>A genetic reassortment resulting in extended changes in antigenic properties</p> Signup and view all the answers

    Which virus is prone to antigenic shift and why?

    <p>Influenza virus, due to its segmented genome</p> Signup and view all the answers

    What is viral recombination?

    <p>The generation of a viral progeny presenting stable phenotypic characteristics of both parent viruses</p> Signup and view all the answers

    Which virus is known for having a highly error-prone replicative enzyme?

    <p>Hepatitis B virus</p> Signup and view all the answers

    What is the term used to describe the presence of a swarm of genetically different viral variants in the same infected individual?

    <p>Quasispecies</p> Signup and view all the answers

    Which type of viruses are generally more genetically stable than RNA viruses?

    <p>Herpesviruses</p> Signup and view all the answers

    Which enzyme in HIV replication is responsible for the high mutation rate of the virus?

    <p>Reverse Transcriptase</p> Signup and view all the answers

    Which HCV genotype is significantly more prevalent among patients with liver cirrhosis and those with decompensated liver disease requiring liver transplantation?

    <p>Genotype 1b</p> Signup and view all the answers

    What is the Immediate Precursor of HIV-1?

    <p>SIVcpz</p> Signup and view all the answers

    What is the estimated percentage of HIV isolates that represent recombinants between different subtypes?

    <p>20%</p> Signup and view all the answers

    Which type of inhibitors target the attachment process of the virus?

    <p>Entry inhibitors</p> Signup and view all the answers

    What is the most common mutation pattern associated with lamivudine resistance in HBV?

    <p>M204V+L180M+V173L in RT</p> Signup and view all the answers

    Which virus has a replication strategy that is unique among all DNA viruses?

    <p>HBV</p> Signup and view all the answers

    What is the term used to describe the ability of viruses to change their genetic makeup over time?

    <p>Viral evolution</p> Signup and view all the answers

    Which viruses are subject to antigenic drift?

    <p>Influenza virus, HIV, HBV, HCV</p> Signup and view all the answers

    Which virus is prone to antigenic shift due to the segmented nature of its genome?

    <p>Influenza virus</p> Signup and view all the answers

    What is the phenomenon that occurs during replication of RNA viruses, when the viral enzyme can jump from one template strand to another, dragging the chain of newly synthesized one and with the generation of a hybrid polynucleotide strand?

    <p>Viral recombination</p> Signup and view all the answers

    What is the term used to describe the exchange of homologous stretches of genetic material between two virus strains co-infecting the same cell, with the generation of a viral progeny presenting stable phenotypic characteristics of both parent viruses?

    <p>Viral recombination</p> Signup and view all the answers

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