Laboratory Diagnosis of HSV Infections

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What is the purpose of a Tzanck smear in the laboratory diagnosis of HSV infections?

To detect the presence of multinucleated giant cells, suggesting HSV infection.

How can viral antigens or DNA in vesicular fluid be detected in the laboratory for HSV infections?

Through immunofluorescence, DNA probes, or PCR.

What is the method used to isolate the virus from herpetic lesions?

Immunofluorescence or ELISA.

Describe the clinical presentation of infectious mononucleosis caused by Epstein Barr virus (EBV).

It presents with fever, sore throat, enlarged lymph nodes and spleen, rash, and commonly hepatitis. Signup and view all the answers

How does EBV infection differ when it occurs in adolescence compared to childhood?

In adolescence, 50% of cases manifest as infectious mononucleosis (IMN), while childhood infections are usually asymptomatic. Signup and view all the answers

What laboratory test can be performed to detect heterophils antibodies in the diagnosis of infectious mononucleosis?

Paul Bunnel test. Signup and view all the answers

What clinical forms can CMV infection take in the normal host?

Asymptomatic latent infection or infectious mononucleosis-like syndrome Signup and view all the answers

What are the clinical manifestations of congenital CMV infection?

Abortion, still-birth, cytomegalic inclusion disease with congenital anomalies like blindness, deafness, mental retardation Signup and view all the answers

How can CMV infection be diagnosed?

Detection of intranuclear cytomegalic inclusions, CMV nucleic acids in tissues, isolation of virus from throat washings and urine, detection of IgM or rising titer of IgG Signup and view all the answers

What clinical manifestations does CMV infection cause in immunocompromised hosts?

Pneumonia, retinitis, graft rejection, disseminated disease Signup and view all the answers

What is the association observed between CMV and coronary angioplasty?

Restenosis Signup and view all the answers

What type of antibodies are typically absent in CMV infectious mononucleosis-like syndrome in the normal host?

Heterophile antibodies Signup and view all the answers

What is the etiology of viral lymphadenitis according to Dr. Amal Hassan Salama?

Epstein-Barr virus, cytomegalovirus, HIV, Herpes simplex virus, Measles, Mumps, Rubella, Coxsackie, Adenovirus Signup and view all the answers

Describe the characteristics of Rubella (German Measles) as outlined by Dr. Amal Hassan Salama.

Rubella is an acute infectious disease characterized by fever, rash, and enlargement of occipital and cervical lymph nodes. It is caused by a single stranded RNA virus belonging to the Togavirus family. Signup and view all the answers

Explain the transmission mode of Rubella virus according to Dr. Amal Hassan Salama.

Rubella virus is not transmitted by arthropods. It is transmitted by infection of neonates, children, and adults through respiratory droplets. Signup and view all the answers

Describe the process of infection in postnatal Rubella according to Dr. Amal Hassan Salama.

Initial replication of the virus occurs in the nasopharynx and local lymph nodes, then spreads via the blood to internal organs and skin. This leads to the appearance of a maculopapular rash, fever, and enlargement of cervical or occipital lymph nodes. Signup and view all the answers

What are the characteristics of Congenital Rubella Syndrome as described by Dr. Amal Hassan Salama?

Congenital Rubella Syndrome occurs when Rubella infection of pregnant women leads to transplacental transmission to the fetus. This can result in congenital anomalies like heart defects, cataract, deafness, blindness, and mental retardation. Signup and view all the answers

What are the possible congenital anomalies associated with Rubella infection in pregnant women according to Dr. Amal Hassan Salama?

Congenital heart defects, cataract, deafness, blindness, meningoencephalitis, mental retardation, hepatosplenomegaly Signup and view all the answers

Laboratory Diagnosis of HSV Infections

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Questions and Answers

What is the purpose of a Tzanck smear in the laboratory diagnosis of HSV infections?

How can viral antigens or DNA in vesicular fluid be detected in the laboratory for HSV infections?

What is the method used to isolate the virus from herpetic lesions?

Describe the clinical presentation of infectious mononucleosis caused by Epstein Barr virus (EBV).

How does EBV infection differ when it occurs in adolescence compared to childhood?

What laboratory test can be performed to detect heterophils antibodies in the diagnosis of infectious mononucleosis?

What clinical forms can CMV infection take in the normal host?

What are the clinical manifestations of congenital CMV infection?

How can CMV infection be diagnosed?

What clinical manifestations does CMV infection cause in immunocompromised hosts?

What is the association observed between CMV and coronary angioplasty?

What type of antibodies are typically absent in CMV infectious mononucleosis-like syndrome in the normal host?

What is the etiology of viral lymphadenitis according to Dr. Amal Hassan Salama?

Describe the characteristics of Rubella (German Measles) as outlined by Dr. Amal Hassan Salama.

Explain the transmission mode of Rubella virus according to Dr. Amal Hassan Salama.

Describe the process of infection in postnatal Rubella according to Dr. Amal Hassan Salama.

What are the characteristics of Congenital Rubella Syndrome as described by Dr. Amal Hassan Salama?

What are the possible congenital anomalies associated with Rubella infection in pregnant women according to Dr. Amal Hassan Salama?

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