11 Questions
Which type of gene rearrangement results in receptors of different specificities being generated?
Rearrangement of VDJ gene segments
Which type of T cells express receptors not composed of α and β chains but instead gamma and delta chains?
Gamma delta T cells
Which cells recognize lipid antigens displayed by MHC-like molecules known as CD1?
NK-T cells
Which is true about the gene arrangement of Kappa light chain immunoglobulin genes?
Variable domains are comprised of VDJ segments
What is the fate of introns in immunoglobulin genes during mRNA processing?
Introns are removed to form exons-only mature mRNA
Where do B cells undergo VDJ recombination?
Bone marrow
What limits the combinatorial diversity of antigen receptors?
Number of available VDJ gene segments
What is a characteristic of NK-T cells in terms of their origin?
Originate from common lymphoid progenitors
What is one characteristic that differentiates gamma delta T cells from alpha beta T cells?
Broad specificity similar to innate immune system cells
In what percentage do gamma delta T cells make up the T cell population in the body?
5-10%
What is true about the genetic composition of gamma delta TCRs?
They can recognize protein and non-protein antigens
Test your knowledge on the gene arrangement of Kappa light chain immunoglobulin genes and the role of introns in immunoglobulin genes. Learn about gene expression, gene protein structure, intron-exon organization, and mRNA processing.
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