Kappa Opioid Receptors and Analgesics
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Questions and Answers

Which medication is the most effective for symptomatic treatment?

  • Amantadine
  • Istradefylline
  • Levodopa + Carbidopa (correct)
  • Selegiline
  • What is the minimum amount of carbidopa required to prevent conversion of levodopa outside of the central nervous system (CNS)?

  • 50mg/day
  • 100mg/day
  • 25mg/day
  • 75mg/day (correct)
  • What is the characteristic feature of long-term treatment with Levodopa/Carbidopa (Sinemet)?

  • Psychotic disorder
  • Dyskinesias
  • Protein restriction
  • Fluctuations in motor function (correct)
  • What is the recommended approach to combat the 'wearing off' phenomenon in patients on Levodopa/Carbidopa (Sinemet)?

    <p>Increase frequency of carbidopa/L-dopa doses</p> Signup and view all the answers

    Which of the following is a characteristic of Huntington's Disease?

    <p>Uncontrolled movements</p> Signup and view all the answers

    Which of the following drugs deplete dopamine and other monoamines from the axon terminus by preventing intraneuronal storage?

    <p>Reserpine</p> Signup and view all the answers

    Which of the following drugs is a non-competitive NMDA antagonist and can be used alone or in combination with an anticholinesterase for the treatment of moderate-severe Alzheimer's Disease?

    <p>Memantine</p> Signup and view all the answers

    Which of the following drugs is a monoclonal antibody against aggregated amyloid-beta and reduces plaques in a dose- and time-dependent manner?

    <p>Aducanumab</p> Signup and view all the answers

    Which one of the following opioids is a partial mu agonist and a kappa antagonist?

    <p>Buprenorphine</p> Signup and view all the answers

    Which opioid is known for its antimuscarinic effects and potential for producing seizures?

    <p>Meperidine</p> Signup and view all the answers

    Which opioid is a weak mu agonist and also inhibits the reuptake of serotonin and norepinephrine?

    <p>Tramadol</p> Signup and view all the answers

    Which opioid antagonist is usually given intravenously and has a short duration of action?

    <p>Naloxone</p> Signup and view all the answers

    Which of the following is a characteristic of Parkinsonism?

    <p>Hypokinesia (slow movements)</p> Signup and view all the answers

    Which part of the basal ganglia is responsible for motor control and is affected in Parkinson's Disease?

    <p>Substantia nigra (SN)</p> Signup and view all the answers

    Which dopamine pathway is primarily affected in Parkinson's Disease?

    <p>Nigrostriatal pathway</p> Signup and view all the answers

    What is the role of D2 receptors in the indirect pathway of movement control?

    <p>Inhibit movement</p> Signup and view all the answers

    Which of the following is a side effect of Lecanemab-irmd (Leqembi)?

    <p>Hypersensitivity reactions</p> Signup and view all the answers

    What is the black box warning for Donanemab?

    <p>Increased risk for mortality in older adults with dementia related psychosis</p> Signup and view all the answers

    Which opioid receptor is primarily involved in reward (euphoria) and analgesia?

    <p>Mu receptor</p> Signup and view all the answers

    Which opioid receptor is primarily involved in dysphoria and sedation?

    <p>Kappa receptor</p> Signup and view all the answers

    Which type of MAO metabolizes NE and 5-HT?

    <p>MAOA</p> Signup and view all the answers

    Which adverse effect is associated with the use of selegiline?

    <p>Insomnia</p> Signup and view all the answers

    What is the mechanism of action of muscarinic receptor antagonists?

    <p>Modulating cholinergic activity</p> Signup and view all the answers

    What is the recommended initial treatment for mild-to-moderate impairment/early Parkinson's disease?

    <p>Amantadine</p> Signup and view all the answers

    Which of the following strategies can be used to decrease the activation of somatic motor neurons in spasticity?

    <p>Decreasing the activity of inhibitory interneurons within the spinal cord</p> Signup and view all the answers

    Which muscle relaxant acts as a GABAB receptor agonist and decreases the activity of somatic motor neurons both pre- and post-synaptically?

    <p>Baclofen</p> Signup and view all the answers

    Which muscle relaxant enhances GABAA receptor activity post-synaptically and provides inhibition of somatic motor neurons?

    <p>Diazepam</p> Signup and view all the answers

    Which muscle relaxant acts as an alpha2 receptor agonist and is comparable in efficacy to diazepam and baclofen?

    <p>Tizanidine</p> Signup and view all the answers

    Which centrally acting skeletal muscle relaxant acts primarily in the brain stem, not the spinal cord?

    <p>Cyclobenzaprine</p> Signup and view all the answers

    Which local anesthetic preferentially binds and blocks sodium channels in their activated and inactivated states?

    <p>Local anesthetics preferentially bind and block sodium channels in their activated state</p> Signup and view all the answers

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