30 Questions
Which process is responsible for the direct synthesis of ATP without the involvement of the electron transport chain?
Substrate-level phosphorylation
What is the primary role of the electron transport chain in the mitochondria?
To oxidize reducing equivalents and act as a proton pump
Which of the following electron carriers is not a nucleotide-based cofactor?
FMN
Which of the following is a feature of the mitochondrial membranes?
The outer membrane is selectively permeable to metabolites
What is the role of the citric acid cycle in ATP synthesis?
It provides reducing equivalents (NADH and FADH2) to the electron transport chain
Which of the following is the primary source of energy for the electron transport chain?
All of the above
What is the total number of ATP molecules produced from the oxidation of 1 Acetyl-CoA in the citric acid cycle?
4 ATP
How many protons (H+) are pumped from the matrix into the intermembrane space when the electron pair (2 electrons) enters the respiratory chain via NADH+H?
10 H+
Where does the electron pair (2 electrons) carried with FADH2 enter the respiratory chain?
Complex II
What is the purpose of the Malate-Aspartate shuttle?
To transfer NADH+H from the cytosol to the mitochondrial matrix
Where does Coenzyme Q accept electrons in the electron transport chain?
From Complex II
How many protons (H+) are pumped from the matrix into the intermembrane space when the electron pair (2 electrons) enters the respiratory chain via FADH2?
6 H+
Which of the following correctly describes the flow of electrons in the respiratory chain?
Complex I - coenzyme Q - Complex III - cytochrome c - Complex IV - O2 (for NADH)
What is the primary role of coenzyme Q in the respiratory chain?
To act as a receptor for the respiratory chain complexes
Which of the following complexes in the respiratory chain are responsible for pumping protons into the intermembrane space?
Complex I, Complex III, and ATP synthase
What is the primary function of the proton gradient generated during the respiratory chain?
To drive the synthesis of ATP by ATP synthase
Which of the following statements is true regarding the respiratory chain complexes?
They contain metal ions to facilitate electron flow
What is the final electron acceptor in the respiratory chain?
Oxygen (O2)
Which statement about the phospholipid cardiolipin is correct?
It associates with enzymes of the respiratory chain and ATP synthase.
Which complex is involved in both the respiratory chain and the Krebs cycle?
Complex II (Succinate dehydrogenase)
What is the role of Coenzyme Q in the respiratory chain?
It is a mobile component that shuttles electrons between complexes.
Which statement about the mitochondrial inner membrane is correct?
It is impermeable to hydrogen ions ($H^+$).
What is the final electron acceptor in the respiratory chain?
Oxygen ($O_2$)
Which component of the respiratory chain is responsible for synthesizing ATP?
Complex V (ATP synthase)
What happens when a symporter of Pi and H+ transports these molecules into the matrix?
ATP synthesis stops
Which of the following is a Complex IV inhibitor in the respiratory chain?
CO
What is the main function of uncouplers in the respiratory chain?
Collapse the proton gradient
Which compound is considered the most important uncoupler in the respiratory chain?
2,4-dinitrophenol
What role does Thermogenin play as an uncoupling protein in animals?
Generates body heat
Which of the following is NOT a Complex I inhibitor in the respiratory chain?
Dimercaprol (BAL)
This quiz covers the Electron Transport Chain (ETC) and Oxidative Phosphorylation, focusing on ATP synthesis through substrate-level phosphorylation and oxidative phosphorylation. Topics include glycolysis, citric acid cycle, and the functions of the respiratory chain in mitochondria.
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