Biosynthesis of Triacylglycerol and Phospholipid
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Questions and Answers

What is the precursor of the glycerolipids found in cell membranes and the blood lipoproteins?

  • Triacylglycerols
  • Glycerol 3-P
  • Phosphatidic acid (correct)
  • Acyl-CoA

    • Which enzyme is responsible for converting phosphatidic acid to 1,2-diacyl glycerol?

  • Acyl-CoA synthetase
  • Glycerol-3-P-acyltransferase
  • Phosphatidate phosphohydrolase (correct)
  • 1-acyl glycerol-3-P-acyl transferase

    • What is the source of glycerol in the liver for triacylglycerol synthesis?

  • Acyl-CoA synthetase
  • Phosphorylation of glycerol by glycerol kinase (correct)
  • The reduction of glycolysis
  • Glycolysis

    • What is the role of acyl-CoA synthetase in triacylglycerol synthesis?

    <p>To activate fatty acids by forming acyl-CoA</p> Signup and view all the answers

    Where does the synthesis of triacylglycerols occur?

    <p>Both in the liver and adipose tissue</p> Signup and view all the answers

    What is the intermediate formed in the first stage of phosphatidic acid synthesis?

    <p>Lysophosphatidic acid</p> Signup and view all the answers

    What is the substrate required for the synthesis of phosphatidyl inositol?

    <p>1,2-diacyl glycerol-phosphate</p> Signup and view all the answers

    What is the product formed by the reaction of CTP with phosphatidate?

    <p>CDP-diacyl glycerol</p> Signup and view all the answers

    What is the byproduct of phosphatidyl-inositol, 4,5 - biphosphate breakdown?

    <p>Diacyl glycerol</p> Signup and view all the answers

    What is the chemical structure of cardiolipin?

    <p>Di-phosphatidyl glycerol</p> Signup and view all the answers

    What is the substrate required for the synthesis of cardiolipin?

    <p>α-Glycero-P</p> Signup and view all the answers

    What is the role of certain protein hormones in the breakdown of phosphatidyl-inositol, 4,5 - biphosphate?

    <p>Increase Ca++ inside the cell</p> Signup and view all the answers

    What is the enzyme that catalyses the formation of triacylglycerol from diacyl glycerol and acyl-CoA?

    <p>Diacylglycerol acyltransferase</p> Signup and view all the answers

    What is the reactant that forms phosphocholine or phosphoethanolamine when reacting with ATP?

    <p>Choline or ethanolamine</p> Signup and view all the answers

    What is the product formed when CDP-choline reacts with 1, 2-diacyl glycerol?

    <p>Phosphatidyl choline</p> Signup and view all the answers

    What is the nitrogenous base that is transferred to 1, 2-diacyl glycerol to form phosphatidyl serine?

    <p>Serine</p> Signup and view all the answers

    What is the molecule that donates the ~CH3 group in the alternative pathway of phosphatidyl choline synthesis?

    <p>S-adenosylmethionine</p> Signup and view all the answers

    What is the product formed when phosphatidyl ethanolamine reacts with serine?

    <p>Phosphatidyl serine</p> Signup and view all the answers

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