Triacylglycerol Structure and Storage

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Questions and Answers

What is the yield from the complete oxidation of fatty acids to CO2 and H2O?

  • 12 kcal/g fat
  • 10 kcal/g fat
  • 7 kcal/g fat
  • 9 kcal/g fat (correct)

What is the first step in the mobilization of stored fat?

  • Hydrolytic release of fatty acids and glycerol from TAG (correct)
  • Phosphorylation of hormone-sensitive lipase
  • Activation of protein kinase A
  • Release of fatty acids from TAG by lipases

What is the product of hormone-sensitive lipase (HSL) action?

  • Glycerol
  • Diacylglycerol
  • Triacylglycerol
  • Monoacylglycerol (correct)

What is required for hormone-sensitive lipase (HSL) to be active?

<p>Phosphorylation by protein kinase A (C)</p> Signup and view all the answers

What happens to hormone-sensitive lipase (HSL) in the presence of high plasma levels of insulin?

<p>It becomes dephosphorylated and inactivated (B)</p> Signup and view all the answers

What happens to glycerol released during TAG degradation in adipocytes?

<p>It is transported to the liver for phosphorylation (B)</p> Signup and view all the answers

What is the purpose of perilipin phosphorylation by PKA?

<p>To allow translocation and binding of HSL to the droplet (A)</p> Signup and view all the answers

What is the role of adenylyl cyclase in the regulation of hormone-sensitive lipase?

<p>To produce cAMP and activate PKA (D)</p> Signup and view all the answers

What is the function of glycerol 3-phosphate in TAG synthesis?

<p>It is the initial acceptor of fatty acids during TAG synthesis. (D)</p> Signup and view all the answers

Where is glycerol 3-phosphate primarily produced in the body?

<p>Liver (C)</p> Signup and view all the answers

What is the purpose of activating a free fatty acid?

<p>To participate in metabolic processes such as TAG synthesis (C)</p> Signup and view all the answers

What is the primary energy reserve of the body?

<p>TAGs stored in white adipocytes (D)</p> Signup and view all the answers

In which type of cells are TAGs primarily stored?

<p>White adipocytes (D)</p> Signup and view all the answers

What is the purpose of the glucose transporter in adipocytes?

<p>To synthesize TAGs de novo (A)</p> Signup and view all the answers

What happens to TAGs when they are stored in adipose tissue?

<p>They coalesce to form large oily droplets (D)</p> Signup and view all the answers

What is the function of fatty acyl CoA synthetases?

<p>To activate fatty acids for TAG synthesis (C)</p> Signup and view all the answers

What is the energy yield from the oxidation of a molecule of palmitoyl CoA to CO2 and H2O?

<p>129 ATP (C)</p> Signup and view all the answers

What is required for the activation of the fatty acid?

<p>2 ATP (A)</p> Signup and view all the answers

What is the product of the β-oxidation pathway of palmitoyl CoA?

<p>7 NADH and 7 FADH2 (B)</p> Signup and view all the answers

What is the byproduct of the metabolism of certain amino acids?

<p>Propionyl CoA (C)</p> Signup and view all the answers

What is the first step in the metabolism of propionyl CoA?

<p>Carboxylation (B)</p> Signup and view all the answers

What is the coenzyme required for the enzyme propionyl CoA carboxylase?

<p>Biotin (C)</p> Signup and view all the answers

Fatty acids with an odd number of carbons are metabolized by which reaction steps?

<p>The same reaction steps as fatty acids with an even number of carbons (A)</p> Signup and view all the answers

What is the product of the metabolism of propionyl CoA?

<p>D-methylmalonyl CoA (C)</p> Signup and view all the answers

Which enzyme is responsible for cleaving HMG CoA to produce acetoacetate and acetyl CoA?

<p>HMG CoA lyase (C)</p> Signup and view all the answers

Which compound is a volatile, biologically nonmetabolized product that can be released in the breath?

<p>Acetone (B)</p> Signup and view all the answers

What determines the equilibrium between acetoacetate and 3-hydroxybutyrate?

<p>NAD+/NADH ratio (D)</p> Signup and view all the answers

During fatty acid oxidation, which ketone body synthesis is favored due to a low NAD+/NADH ratio?

<p>3-Hydroxybutyrate (C)</p> Signup and view all the answers

Which product is actively removed by its conversion to two acetyl CoAs in ketolysis?

<p>Acetoacetyl CoA (D)</p> Signup and view all the answers

Which enzyme oxidizes 3-hydroxybutyrate to acetoacetate?

<p>3-Hydroxybutyrate dehydrogenase (A)</p> Signup and view all the answers

During fasting, what role do ketone bodies play in the body?

<p>Provide energy to peripheral tissues (D)</p> Signup and view all the answers

Which enzyme provides acetoacetate with a CoA molecule taken from succinyl CoA?

<p>Thiophorase (B)</p> Signup and view all the answers

Which molecule is produced when serine is combined with PA?

<p>phosphatidylserine (B)</p> Signup and view all the answers

What is cardiolipin composed of?

<p>Two molecules of PA esterified with glycerol (D)</p> Signup and view all the answers

Where is cardiolipin predominantly found in eukaryotes?

<p>Inner mitochondrial membrane (C)</p> Signup and view all the answers

What defines a plasmalogen?

<p>A glycerophospholipid with an unsaturated alkyl group at carbon 1 (D)</p> Signup and view all the answers

Which tissue has an abundance of phosphatidalethanolamine?

<p>Nerve tissue (A)</p> Signup and view all the answers

What forms the backbone of sphingomyelin?

<p>Sphingosine (B)</p> Signup and view all the answers

Which constituent of nerve fibers is sphingomyelin particularly important for?

<p>Myelin sheath (A)</p> Signup and view all the answers

What type of linkage attaches a long-chain fatty acid to sphingosine in sphingomyelin?

<p>Amide linkage (C)</p> Signup and view all the answers

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