PLP Biochemistry Quiz: Functions of Pyridoxal Phosphate

Study Notes

Pyridoxal Phosphate (PLP) Reactions

PLP participates in various reactions, including transamination, decarboxylation, and deamination of amino acids.
It also plays a role in the synthesis of neurotransmitters, such as serotonin and dopamine.

Role of PLP in Amino Acid Metabolism

PLP acts as a coenzyme in amino acid metabolism, facilitating the conversion of amino acids into other amino acids, carbohydrates, or fatty acids.
It helps break down amino acids into alpha-keto acids, which can then be used for energy production or glucose synthesis.

Recommended Dietary Allowance (RDA) of Pyridoxine

The recommended daily intake of pyridoxine is 1.3-1.5 mg for adult men and 1.1-1.3 mg for adult women.

Integration of Carbohydrate and Amino Acid Metabolisms

Pyridoxine helps integrate carbohydrate and amino acid metabolisms by facilitating the conversion of amino acids into glucose or glycogen.

Role of Pyridoxine in Specialized Product Metabolism

Pyridoxine is necessary for the synthesis of certain specialized products, such as neurotransmitters, hormones, and antioxidants.
It plays a role in the metabolism of sulfur-containing amino acids, such as cysteine and methionine.

Transamination Reaction

PLP is involved in the transamination reaction, which allows for the transfer of amino groups between amino acids and alpha-keto acids.

Pyridoxine Intake Changes

The recommended daily intake of pyridoxine increases during pregnancy (1.9-2.0 mg) and lactation (2.0 mg), and decreases with old age (1.5-1.7 mg).

Contribution to Metabolism

Pyridoxine is essential for the metabolism of amino acids, carbohydrates, and fats, and plays a crucial role in maintaining overall health and well-being.

Description

Test your knowledge of the biochemical functions of pyridoxal phosphate (PLP), the coenzyme of vitamin B6. Learn about its role in the metabolism of amino acids and its participation in reactions like transamination, decarboxylation, and condensation.