15 Questions
What is the main cause of Benign Prostatic Hyperplasia (BPH)?
Hyperplasia of both the epithelial and stromal component of the gland.
Where does BPH originate in the prostate?
Transition and pre-prostatic zone at the level of periurethral region.
Why is it important to target both the epithelial and stromal components in BPH therapy?
Because BPH is due to hyperplasia of both components.
What type of process characterizes BPH?
Hyperplasia, not hypertrophy.
How can all pathological processes in the prostate affect voiding?
Result in voiding phase problems.
What is the major cause of benign prostatic hyperplasia (BPH)?
An alteration in the local balance between estrogen and androgens
Which enzyme is the target of a drug against BPH?
5-alpha reductase 11
What is the primary androgen responsible for the growth of the prostate?
Dihydrotestosterone (DHT)
What are the most common voiding phase symptoms experienced by a patient with BPH?
Post-voiding dribbling, increased residual urine volume, overflow incontinence / paradoxical ischuria
What characterizes the location of prostatic cancer development in the prostate?
Peripheral portion
What distinguishes Benign Prostatic Hyperplasia (BPH) from hypertrophy?
Hyperplasia is an increase in volume and number of cells, while hypertrophy is an increase only in the volume of cells.
Where does BPH primarily originate in the prostate gland?
BPH originates in the transition and pre-prostatic zone at the level of the periurethral region.
What age group is most commonly affected by Benign Prostatic Hyperplasia?
Men over 45 years old, with high prevalence in those in their 50s or 60s.
How does the prevalence of BPH change with age based on histological examination?
The prevalence of BPH increases progressively from 30 years old, up to 90% in the ninth decade of age.
Why is it crucial to consider BPH in the differential diagnosis of older patients?
BPH has a high prevalence in older patients, and nearly all individuals over 70 years old exhibit signs of BPH.
Learn about benign prostatic hyperplasia (BPH), a condition characterized by hyperplasia of both the epithelial and stromal components in the prostate gland. Understand the difference between hypertrophy and hyperplasia and the targeted therapy for BPH.
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