6 Questions
What is the end result of Syk tyrosine kinase phosphorylating tyrosine residues on adaptor proteins in B cells?
Recruit and activate enzymes to initiate signaling cascades
What facilitates the migration of B cells from the follicle to the T cell zone?
Decreasing CXCR5 expression
What is a functional consequence of antigen binding to naïve B lymphocytes?
Activation of B cell proliferation and IgM secretion
After the T-B interaction and the development of long-lived plasma cells, where does the antibody response fully develop?
Germinal centers
What stimulates heavy-chain isotype switching and affinity maturation during the B-T cell interaction?
Dendritic cell interactions with B cells
What transduces the signal when antigen binds to the antigen-binding domain of the B-cell receptor (BCR)?
Immunoreceptor tyrosine-based activation motif (ITAM)
Test your knowledge on the B-cell receptor signaling pathway! Learn about the components involved in transducing signals when antigens bind to the receptor, as well as the end result of Syk tyrosine kinase activity on adaptor proteins in B cells.
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