W B Lymphocyte Development
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Questions and Answers

Where are B-1 cells primarily found?

  • In lymph node germinal centers
  • In peripheral blood lymphocytes
  • In adults' bone marrow
  • In the fetus and neonate (correct)

    • What is the main characteristic of antibodies secreted by B-1 cells?

  • High affinity and can bind to a specific antigen
  • Low affinity and can bind to many different antigens (correct)
  • High affinity and can bind to many different antigens
  • Low affinity and can bind to a specific antigen

    • Which chromosomes contain the light chain loci for antibody construction?

  • Chromosome 22
  • Chromosome 14
  • Chromosomes 2 and 22 (correct)
  • Chromosome 2

    • What is the process that B cells use to further recombine the antibody heavy chain genes?

    <p>Isotype or class switching</p> Signup and view all the answers

    Which cells secrete cytokines that program the activated B cell to undergo class switching?

    <p>Helper T cells</p> Signup and view all the answers

    What promotes the differentiation into plasma cells that secrete IgM and promotes class switching to IgG2, IgG4, IgA, and IgE?

    <p>IL-4, IL-5, and TGF-β secreted by Th2 cells</p> Signup and view all the answers

    What is responsible for the production of isoantibody to the ABO substance?

    <p>B-1 cells</p> Signup and view all the answers

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