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Questions and Answers
Which stage of B-cell development involves the rearrangement of heavy and light chains, and the roles of RAG-1, RAG-2, and TdT?
Which stage of B-cell development involves the rearrangement of heavy and light chains, and the roles of RAG-1, RAG-2, and TdT?
- Mature B-cells
- Activated B-cells
- Naïve B-cells
- Immature B-cells (correct)
What is the consequence of failure to achieve central and peripheral tolerance in B-cells?
What is the consequence of failure to achieve central and peripheral tolerance in B-cells?
- Enhanced B-cell activation
- Increased affinity maturation
- Autoimmune diseases (correct)
- Decreased somatic hypermutation
Which cell type is responsible for producing antibodies at the highest level during a secondary immune response?
Which cell type is responsible for producing antibodies at the highest level during a secondary immune response?
- Plasma cells (correct)
- Naïve B-cells
- Immature B-cells
- Memory B-cells
What is the primary function of activation-induced cytidine deaminase (AID) in B-cell activation and differentiation?
What is the primary function of activation-induced cytidine deaminase (AID) in B-cell activation and differentiation?
How does the response of a B-cell to a T-independent antigen differ from the response to a T-dependent antigen?
How does the response of a B-cell to a T-independent antigen differ from the response to a T-dependent antigen?
What is the main function of B-1 cells?
What is the main function of B-1 cells?
Where does the development of B cells occur?
Where does the development of B cells occur?
Which chromosome contains about 60 Variable (V) regions for heavy chain locus?
Which chromosome contains about 60 Variable (V) regions for heavy chain locus?
What is the process by which B cells recombine the antibody heavy chain genes to use with other constant (C) genes?
What is the process by which B cells recombine the antibody heavy chain genes to use with other constant (C) genes?
Which cytokines promote the differentiation of B cells into plasma cells and class switching to IgG2, IgG4, IgA, and IgE?
Which cytokines promote the differentiation of B cells into plasma cells and class switching to IgG2, IgG4, IgA, and IgE?
Which surface marker characterizes early Pro-B cells in the B cell lineage?
Which surface marker characterizes early Pro-B cells in the B cell lineage?
What is the main event in the early Pro-B cell stage?
What is the main event in the early Pro-B cell stage?
What complex is formed when the heavy chain, surrogate light chain, Ig, and Igβ associate with the BCR to resemble the BCR?
What complex is formed when the heavy chain, surrogate light chain, Ig, and Igβ associate with the BCR to resemble the BCR?
Which process ensures that a B cell only expresses one of its two copies of the heavy chain genes?
Which process ensures that a B cell only expresses one of its two copies of the heavy chain genes?
What occurs when a functional light chain is formed in pre-B cells?
What occurs when a functional light chain is formed in pre-B cells?
What triggers an immature self-reactive B cell to become anergic?
What triggers an immature self-reactive B cell to become anergic?
Which cytokines are involved in B-cell activation?
Which cytokines are involved in B-cell activation?
What is the main function of memory B cells?
What is the main function of memory B cells?
Which surface molecule triggers the activation and division of B cells when bound to CD40L?
Which surface molecule triggers the activation and division of B cells when bound to CD40L?
What type of antigens can activate B cells without requiring T cell help?
What type of antigens can activate B cells without requiring T cell help?
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