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Immune Response and B Cell Activation

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Questions and Answers

What is the primary mechanism by which antigens are captured and presented to B cells in lymphoid tissue?

Antigen-presenting cells, such as dendritic cells, process and present antigens to B cells (correct)

Helper T cells present antigens to B cells through direct cell-to-cell contact

B cells directly capture antigens through their surface-bound immunoglobulins

Antigens are freely diffused throughout lymphoid tissue and encounter B cells by chance

Which of the following signals is required for B cell activation, but not for thymus-independent antigens?

Signal from the complement system

Signal from the germinal center

Signal through the B cell antigen receptor

Signal from the helper T cell through CD40L and cytokines (correct)

What is the process by which antibodies are modified to have higher affinity for antigens?

Clonal selection and expansion

Antigen presentation and processing

Isotype switching and class switching

Somatic hypermutation and affinity maturation (correct)

Which of the following is NOT a mechanism by which antibodies protect the host from infection?

Phagocytosis Signup and view all the answers

What is the primary function of the germinal center in the context of B cell activation?

B cell proliferation and differentiation Signup and view all the answers

Which of the following cytokines is NOT involved in B cell activation and differentiation?

IL-12 Signup and view all the answers

What is the primary mechanism by which helper T cells provide a second signal for B cell activation?

Cytokine signaling through CD40L Signup and view all the answers

Which of the following is a characteristic of natural antibodies?

They are produced by plasma cells in the absence of antigen stimulation Signup and view all the answers

What is the primary function of plasma cells in the context of humoral immunity?

Antibody production and secretion Signup and view all the answers

Which of the following is a requirement for B cell activation and differentiation?

Antigen binding to the B cell antigen receptor Signup and view all the answers