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Questions and Answers
What is the specific chemokine receptor expressed by conventional dendritic cells upon activation?
What is the specific chemokine receptor expressed by conventional dendritic cells upon activation?
- CCR5
- CCR7 (correct)
- CXCR4
- CXCR5
Where do the chemokines produced by lymphatic endothelium and stromal cells in the T cell zones of lymph nodes direct the dendritic cells to migrate?
Where do the chemokines produced by lymphatic endothelium and stromal cells in the T cell zones of lymph nodes direct the dendritic cells to migrate?
- Lymph nodes (correct)
- Thymus
- Bone marrow
- Spleen
What reflects the maturation of dendritic cells during migration from the epithelium to lymph nodes?
What reflects the maturation of dendritic cells during migration from the epithelium to lymph nodes?
- Increased synthesis of T cell receptors
- Decreased expression of costimulators
- Stable expression of chemokine receptors
- Increased synthesis and stable expression of MHC molecules (correct)
What is the role of the chemokine receptor CCR7 in conventional dendritic cells upon activation?
What is the role of the chemokine receptor CCR7 in conventional dendritic cells upon activation?
What characterizes the maturation of dendritic cells during migration from the epithelium to lymph nodes?
What characterizes the maturation of dendritic cells during migration from the epithelium to lymph nodes?
Where do the chemokines produced by lymphatic endothelium and stromal cells in the T cell zones of lymph nodes direct the dendritic cells to migrate?
Where do the chemokines produced by lymphatic endothelium and stromal cells in the T cell zones of lymph nodes direct the dendritic cells to migrate?
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Study Notes
Dendritic Cell Migration and Maturation
- Conventional dendritic cells express the specific chemokine receptor CCR7 upon activation.
- Chemokines produced by lymphatic endothelium and stromal cells in T cell zones of lymph nodes direct dendritic cells to migrate to these zones.
- The maturation of dendritic cells during migration from epithelium to lymph nodes is reflected by their increased antigen-presenting capacity.
- The chemokine receptor CCR7 plays a crucial role in conventional dendritic cells upon activation, directing them to migrate to lymph nodes.
- The maturation of dendritic cells during migration is characterized by increased antigen-presenting capacity and expression of CCR7.
- Activated dendritic cells migrate to T cell zones of lymph nodes in response to chemokines produced by lymphatic endothelium and stromal cells.
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