6 Questions
What is the specific chemokine receptor expressed by conventional dendritic cells upon activation?
CCR7
Where do the chemokines produced by lymphatic endothelium and stromal cells in the T cell zones of lymph nodes direct the dendritic cells to migrate?
Lymph nodes
What reflects the maturation of dendritic cells during migration from the epithelium to lymph nodes?
Increased synthesis and stable expression of MHC molecules
What is the role of the chemokine receptor CCR7 in conventional dendritic cells upon activation?
It is specific for chemoattracting cytokines produced by lymphatic endothelium and stromal cells
What characterizes the maturation of dendritic cells during migration from the epithelium to lymph nodes?
Increased synthesis and stable expression of MHC molecules and costimulators
Where do the chemokines produced by lymphatic endothelium and stromal cells in the T cell zones of lymph nodes direct the dendritic cells to migrate?
To the lymph nodes draining that epithelium
Study Notes
Dendritic Cell Migration and Maturation
- Conventional dendritic cells express the specific chemokine receptor CCR7 upon activation.
- Chemokines produced by lymphatic endothelium and stromal cells in T cell zones of lymph nodes direct dendritic cells to migrate to these zones.
- The maturation of dendritic cells during migration from epithelium to lymph nodes is reflected by their increased antigen-presenting capacity.
- The chemokine receptor CCR7 plays a crucial role in conventional dendritic cells upon activation, directing them to migrate to lymph nodes.
- The maturation of dendritic cells during migration is characterized by increased antigen-presenting capacity and expression of CCR7.
- Activated dendritic cells migrate to T cell zones of lymph nodes in response to chemokines produced by lymphatic endothelium and stromal cells.
Learn about the process of dendritic cells losing adhesiveness, expressing CCR7, and migrating to lymph nodes upon activation. Understand how chemokines play a role in directing the migration of dendritic cells through lymphatic vessels.
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