18 Questions
What is considered a leading cause of morbidity and mortality in the world?
Atherosclerotic cardiovascular disease
At what age does the development of lipid-rich fibroinflammatory plaque in the arterial intima usually begin?
Early 20s
Which of the following is NOT listed as a classical modifiable vascular risk factor for atherosclerosis?
Genetics
What is considered an acute event in atherosclerosis determined by plaque rupture or erosion?
Plaque rupture
Which of the following is NOT a factor influencing atherogenesis based on the provided text?
Exercise
What is one of the theories of atherogenesis according to the text?
Normal arterial physiology
Which ethnic group is mentioned in the context as having a susceptibility to atherosclerosis?
South Asians
What are the main categories listed under genetics contributing to atherosusceptibility?
Monogenic and Polygenic
Which condition is NOT listed under inflammation as having an influence on atherosclerosis?
Hypertension
What is the main function of tight junctions in endothelial cells?
Maintain a non-thrombotic luminal surface
What is the role of smooth muscle cells (SMCs) in arteries?
Modulate artery diameter to meet metabolic needs
What is the main function of the extracellular matrix (ECM) in arteries?
Provide structural integrity against blood pressure
How do endothelial cells respond to high shear stress (flow)?
Align with the direction of flow and elaborate mediators
What is the significance of FRS (Framingham Risk Score) mentioned in the text?
Predicts 90% of coronary disease incidents globally
What does the MESA study mentioned in the text involve?
Studying asymptomatic patients for cultural differences in CAD risk
What is the role of SMCs when they are in a quiescent state?
Maintain relaxed and non-migratory state
Why is the ECM important for artery physiology?
Provides structural integrity against blood pressure
How do endothelial cells respond to high shear stress?
They align with the direction of flow and elaborate mediators.
Test your knowledge on atherosclerosis, a leading cause of cardiovascular morbidity and mortality worldwide. Explore the processes of atherogenesis, clinical risk factors, and how the cell biology of atherosclerosis can be modified to improve cardiovascular outcomes.
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