WEEK 15.pdf

MYELODYSPLASTIC 15 SYNDROMES (MDS) MYELODYSPLASTIC SYNDROMES(MDS) Group of disorders that result from clonal abnormalities of hematopoietic pluripotential stem cells. Characterized by a hypercellular bone marrow and abnormalities in the cellular maturation of the erythroid cells, gra...

MYELODYSPLASTIC 15 SYNDROMES (MDS) MYELODYSPLASTIC SYNDROMES(MDS) Group of disorders that result from clonal abnormalities of hematopoietic pluripotential stem cells. Characterized by a hypercellular bone marrow and abnormalities in the cellular maturation of the erythroid cells, granulocytes, and megakaryocytes. MDS are a group of acquired clonal hematologic disorders characterized by progressive cytopenias in the peripheral blood, reflecting defects in erythroid, myeloid, and/or megakaryocytic maturation Historically, this pattern of abnormalities was referred to as refractory anemia, smoldering leukemia, oligoblastic leukemia, or preleukemia The median age at diagnosis is 70 TRADITIONAL FAB COOPERATIVE GROUP CLASSIFICATION OF MDSS Blasts in peripheral Blasts in Ringed Peripheral MDS blood BM sideroblasts blood (%) (%) (%) Monocytes Refractory anemia (RA)