Week 13 Lymphoma Types PDF
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Uploaded by SubsidizedEternity
Institute of Health Technology, Dhaka
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Summary
This document provides information on various lymphoma types, including descriptions of their characteristics, features, and associated conditions. Diagrams and explanations of specific cases help illustrate each lymphoma type and cellular components.
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OTHER 13 LYMPHOPROLIFERATIVE DISORDERS HAIRY CELL LEUKEMIA small B lymphocytes with abundant cytoplasm fine (“hairy”) cytoplasmic projections. bone marrow makes too many abnormal B-lymphocytes. More common in males than in women cytochemical features: strong acid phosphatas...
OTHER 13 LYMPHOPROLIFERATIVE DISORDERS HAIRY CELL LEUKEMIA small B lymphocytes with abundant cytoplasm fine (“hairy”) cytoplasmic projections. bone marrow makes too many abnormal B-lymphocytes. More common in males than in women cytochemical features: strong acid phosphatase reactioN not inhibited by tartaric acid or tartrate-resistant acid phosphatase (TRAP) stain. MANTLE CELL LYMPHOMA AFFECTS THE B-cells within the lymph nodes particularly the "mantle zone" - the outer area surrounding the center. A subtype of non-Hodgkin lymphoma (NHL) considered fast-growing compared to other lymphomas. originates from B-cells in the lymph nodes, characterized by medium-sized lymphoid cells with irregular nuclear outlines derived from the follicular mantle zone FOLLICULAR LYMPHOMA Follicular lymphoma originates from germinal center B cells and in most cases recapitulates follicular architecture. Numerous closely spaced follicles replace the normal nodal architecture BURKITT LYMPHOMA Burkitt lymphoma is characterized by medium- sized, highly proliferating lymphoid cells with basophilic vacuolated cytoplasm The lymphoid proliferation is diffuse and at low magnification shows a prominent “starry sky” pattern imparted by numerous tangible body macrophages WHO classification lists three variants of this lymphoma: endemic (occurring predominantly in Africa), sporadic, and immunodeficiency associated. MYCOSIS FUNGOIDES & SEZARY SYNDROME Mycosis fungoides is the most common cutaneous lymphoma It affects T lymphocyte Sezary cells -composed of small to medium-sized lymphoid cells with irregular nuclear outlines (cerebriform nuclei). Sézary syndrome is by definition a disseminated disease with leukemic presentation and skin and lymph node involvement HODGKIN’S LYMPHOMA Malignant lymphoma but differs in that the cells reacting to the neoplasm predominant rather than the neoplastic cells themselves It is divided into 2 broad categories: CLASSICAL HODGKIN NODULAR LYMPHOCYTE PREDOMINANT HODGKIN smaller cells with a hyper-lobulated large, abnormal lymphocytes with a nucleus and small nucleoli. Imagine a characteristic lobed nucleus and popcorn kernel - small and with many prominent eosinophilic inclusions. irregular lobes.
