Veterinary Pathology PDF
Document Details
Uploaded by HardWorkingLute
null
Tags
Summary
This document covers the basics of Veterinary Pathology, including definitions of key terms like 'Pathos', 'Logos', 'Disease', and different diagnostic techniques. It also highlights the field's history, mentioning pioneers like Rudolf Virchow and contemporary examples.
Full Transcript
Veterinary Pathology Definitions 1) Pathos: suffering or disease 2) Logos: study of - reason, divine wisdom 3) Disease: impairment of normal -the manifestation of aberrant physiology 4) Pathogenesis: The mechanism in which a sequence of events from a stimulus leads to disease 5) Morbidity:...
Veterinary Pathology Definitions 1) Pathos: suffering or disease 2) Logos: study of - reason, divine wisdom 3) Disease: impairment of normal -the manifestation of aberrant physiology 4) Pathogenesis: The mechanism in which a sequence of events from a stimulus leads to disease 5) Morbidity: diseased state, ill health - ill (compromised ) health or (compromised) welfare- due to treatment or lack of treatments of a disease 6) Mortality: death Pathology: The study of disease Bridging discipline between basic sciences (physiology, microbiology, anatomy, molecular biology etc.) and clinical sciences (surgery, medicine, dermatology and other ‘ologies’) Specifically, examines relationship between changes in structure and function of cells, tissue and organs, fluids to an underlying disease ‘Underpins every aspect of patient care’- provides information: from diagnosis to treatment Divisions of Pathology: Veterinary Medicine Two divisions: Anatomic pathologist: examines morphological (structural) changes in tissue and organs to identify the cause of disease Clinical pathologist: examines changes in blood (hematology and serum chemistry) and tissue biopsy (cytology) to identify the cause of disease Greeks https://mythus.fandom.com/wiki/Styx_(river) Some contemporary examples 18th and 19th Century veterinary pathologists: skilled butchers, laymen or field veterinarians A pioneer in pathology… Rudolf Virchow: the father of modern pathology: “Cellular Pathology”…seminal work for pathology Pathology: Diagnostics 1) Post mortem: autopsy (people), necropsy (animals – veterinary medicine) Common diagnostic technique (on dead animals)- cost effective and easy to perform: skill of the individual https://partnersah.vet.cornell.edu/veterinarians/bovine-necropsy https://partnersah.vet.cornell.edu/veterinarians/bovine-necropsy Pathology: Diagnostics 2) Light Microscopy: histology and cytology -Common diagnostic technique - Light magnification to observe detailed tissue structure - Various stains are used : to help identify and differentiae tissue structure: Resolution: 200 um What is resolution? Viana et al Ciencia Anaimal Brasileria 2022 Pathology: Diagnostics 3) Electron microscopy: - improved resolution compare to light microscopy (histology) - electron beam: used to provide tissue details - Uncommon diagnostic technique : Older technique – not used for routine diagnostic procedures - Resolution: 1- 200um Three types of EM: -transmission EM: -scanning EM - scanning-transmission Pathology: Diagnostics 4) Immunohistochemistry: antibody bind to antigen - antibody is linked to a marker (fluorochrome of color dye) – visualizing with microscope - Common diagnostic technique Kadam et al Infection, Genetics and Evolution 2022 Headley & Sukuyra Braz J Vet Path 2009 Pathology: Diagnostics 5) Molecular Pathology: Polymerase Chain Reaction (PCR) - Amplify segments of DNA: can amply a single copy of DNA. - Commonly identifies: infectious agents (ie pathogens), tumor biomarkers, and other genetic material - Common diagnostic technique 6) Tissue Microarrays: High throughput technique with PCR technology
