Causes of Hyperuricemia PDF
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University of Sulaimani
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Summary
This document describes the causes of hyperuricemia, categorizing them as primary and secondary causes. Primary causes include idiopathic and familial factors relating to urate excretion and enzymatic defects. Secondary causes are related to increased production or decreased elimination of uric acid. Key factors such as genetic predispositions, renal failure, and purine-rich diets are discussed.
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Causes of hyperuricemia Primary (with no underlying disease) Secondary (with underlying disease) Idiopathic Familial (Decrease urate excretion, with normal renal function) increased production Myeloproliferative disorders Malignancy Genetics: In some cases, a genetic predisposition can Psoriasis lea...
Causes of hyperuricemia Primary (with no underlying disease) Secondary (with underlying disease) Idiopathic Familial (Decrease urate excretion, with normal renal function) increased production Myeloproliferative disorders Malignancy Genetics: In some cases, a genetic predisposition can Psoriasis lead to increased production or reduced excretion of uric Alcohol (nucleotide breakdown) acid, contributing to hyperuricemia. Enzymatic defect on urate pathway (rare) PRPP synthase overactivity HGPRT deficiency (salvage pathway) Decreased elimination Renal failure (acute or chronic) Lactate or ketoacid excess (metabolic acidosis with reduced urate secretion) Drugs like thiazide diuretics Alcohol (increase lactate and ketoacid formation) Excessive purine intake Purine rich diet (high meat and sea food)
