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Questions and Answers
What is the role of purines in the body?
What is the role of purines in the body?
- They are the end products of catabolism of proteins
- They are involved in the breakdown of ATP
- They are responsible for the excretion of uric acid
- They serve as essential building blocks for DNA, RNA, and ATP (correct)
What is the fate of uric acid in the human body?
What is the fate of uric acid in the human body?
- It is broken down into ATP
- It is excreted from the body through the kidneys (correct)
- It is excreted from the body through the liver
- It is converted to allantoin by the enzyme uricase
What is the significance of the enzyme uricase in some species?
What is the significance of the enzyme uricase in some species?
- It breaks down DNA into RNA
- It is involved in the synthesis of proteins
- It converts ATP to ADP
- It converts uric acid to a more soluble compound (correct)
What is the difference between humans and some other species in terms of uric acid metabolism?
What is the difference between humans and some other species in terms of uric acid metabolism?
What is the initial molecule formed in the first step of de novo purine synthesis?
What is the initial molecule formed in the first step of de novo purine synthesis?
Which enzyme is responsible for resynthesizing hypoxanthine and guanine to purine nucleotides?
Which enzyme is responsible for resynthesizing hypoxanthine and guanine to purine nucleotides?
What is the primary function of the de novo synthesis pathway?
What is the primary function of the de novo synthesis pathway?
What is the source of the purine molecules that are resynthesized in the salvage pathway?
What is the source of the purine molecules that are resynthesized in the salvage pathway?
What percentage of urate produced in the body is excreted in the urine?
What percentage of urate produced in the body is excreted in the urine?
What is the term for the breakdown of urate by intestinal bacteria in the gut?
What is the term for the breakdown of urate by intestinal bacteria in the gut?
Hyperuricemia can occur due to which of the following mechanisms?
Hyperuricemia can occur due to which of the following mechanisms?
What is the fate of the remaining 30% of urate produced in the body?
What is the fate of the remaining 30% of urate produced in the body?
Which genetic disorder is characterized by a deficiency in the salvage pathway of purine nucleotide synthesis?
Which genetic disorder is characterized by a deficiency in the salvage pathway of purine nucleotide synthesis?
What is the primary effect of thiazide diuretics on uric acid levels?
What is the primary effect of thiazide diuretics on uric acid levels?
Which dietary factor is likely to contribute to hyperuricemia due to excessive purine intake?
Which dietary factor is likely to contribute to hyperuricemia due to excessive purine intake?
What is the primary mechanism by which myeloproliferative disorders contribute to hyperuricemia?
What is the primary mechanism by which myeloproliferative disorders contribute to hyperuricemia?
What is the primary effect of lactate or ketoacid excess on uric acid levels?
What is the primary effect of lactate or ketoacid excess on uric acid levels?
Which of the following dietary factors is likely to contribute to hyperuricemia due to excessive purine intake?
Which of the following dietary factors is likely to contribute to hyperuricemia due to excessive purine intake?
What is the primary cause of gout?
What is the primary cause of gout?
What is the characteristic of primary gout?
What is the characteristic of primary gout?
What is the complication of gout besides inflammation, pain, and the development of tophi?
What is the complication of gout besides inflammation, pain, and the development of tophi?
What is the difference between primary and secondary gout?
What is the difference between primary and secondary gout?
What is the characteristic of monosodium urate crystals in gout?
What is the characteristic of monosodium urate crystals in gout?
What is the primary method of diagnosing gout and pseudogout?
What is the primary method of diagnosing gout and pseudogout?
What is the relationship between hyperuricemia and gout?
What is the relationship between hyperuricemia and gout?
What is the significance of joint aspiration in diagnosing gout and pseudogout?
What is the significance of joint aspiration in diagnosing gout and pseudogout?
What is the primary benefit of examining synovial fluid in the diagnosis of gout and pseudogout?
What is the primary benefit of examining synovial fluid in the diagnosis of gout and pseudogout?
What is the effect of allopurinol on uric acid levels in the blood?
What is the effect of allopurinol on uric acid levels in the blood?
Which of the following conditions is characterized by an enzymatic defect in the urate pathway?
Which of the following conditions is characterized by an enzymatic defect in the urate pathway?
What is the normal plasma level of uric acid in females?
What is the normal plasma level of uric acid in females?
Which of the following substances can cause a falsely decreased uric acid level in a blood test?
Which of the following substances can cause a falsely decreased uric acid level in a blood test?
What is the purpose of examining synovial fluid under a polarizing light microscope?
What is the purpose of examining synovial fluid under a polarizing light microscope?
Why may a urine uric acid test be ordered in addition to a blood test?
Why may a urine uric acid test be ordered in addition to a blood test?
What is the normal plasma level of uric acid in children?
What is the normal plasma level of uric acid in children?
What can cause a falsely increased uric acid level in a blood test?
What can cause a falsely increased uric acid level in a blood test?
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