Topic 7 - Chromosomal Mutations PDF
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Aston University
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Summary
This document provides an overview of chromosomal mutations, including satellite DNA, tandem repeats, and dispersed repeats. It also discusses telomeric repeats and their role in chromosome integrity.
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🦿 Topic 7 - Chromosomal Mutations Define Satellite DNA Repetitive DNA with an unclear function 2 Major Classes - Alpha Repeats (171 bp) + Beta Repeats (68 bp) Tandem Repeats...
🦿 Topic 7 - Chromosomal Mutations Define Satellite DNA Repetitive DNA with an unclear function 2 Major Classes - Alpha Repeats (171 bp) + Beta Repeats (68 bp) Tandem Repeats tenderly repetitive sequences Mini satellites - short tandem repeats (STRs) Micro satellites - near telomeres Macro Satellites - near centromeres and telomeres, megabases long Telomeric Repeats Clusters of repeated 6bp TTAGGG in humans up to several kb long protect integrity of chromosomes Topic 7 - Chromosomal Mutations 1 Allow the replication of the extreme ends of chromosomes Defects in telomere maintenance involved in cancer and aging Dispersed Repeats interspersed repetitive DNA SINEs (
