sessie 5.pdf

CELMETABOLISME MODULE 1 TG: BOUWSTENEN VAN DE MENS BIOCHEMIE-CELBIOLOGIE Dr. Marcel Bijman [email protected] Developmental BioEngineering, Applied Stem Cell Technologies LEARNING OBJECTIVES After attending this lecture, you should be able to… … describe how cells obtain high-energy molecule...

CELMETABOLISME MODULE 1 TG: BOUWSTENEN VAN DE MENS BIOCHEMIE-CELBIOLOGIE Dr. Marcel Bijman [email protected] Developmental BioEngineering, Applied Stem Cell Technologies LEARNING OBJECTIVES After attending this lecture, you should be able to… … describe how cells obtain high-energy molecules from the breakdown of food … know the function of the starring molecules in this process … understand the contents of the figures, without having to memorize all the details. 3 Chapter 13 How Cells Obtain Energy from Food OXIDATION OF SUGAR CAPTURES ENERGY 5 Copyright © 2023 by W. W. Norton & Company, Inc. MITOCHONDRIA ARE THE ENERGY-FACTORIES 6 Copyright © 2023 by W. W. Norton & Company, Inc. BREAKDOWN OF FOOD GENERATES ENERGY 7 Copyright © 2023 by W. W. Norton & Company, Inc. GLYCOLYSIS 8 Copyright © 2023 by W. W. Norton & Company, Inc.  9 Copyright © 2023 by W. W. Norton & Company, Inc.  10 Copyright © 2023 by W. W. Norton & Company, Inc. FERMENTATION IN ABSENCE OF OXYGEN 11 Copyright © 2023 by W. W. Norton & Company, Inc. ACETYL-CoA IS SYNTHESIZED IN MITOCHONDRIA 12 Copyright © 2023 by W. W. Norton & Company, Inc. THE CITRIC ACID CYCLE 13 Copyright © 2023 by W. W. Norton & Company, Inc.  14 Copyright © 2023 by W. W. Norton & Company, Inc. GLYCOLYSIS + CITRIC ACID CYCLE 15 Copyright © 2023 by W. W. Norton & Company, Inc. OXIDATIVE PHOSPHORYLATION 16 Copyright © 2023 by W. W. Norton & Company, Inc. PART OF A GREAT AMOUNT OF REACTIONS 17 Copyright © 2023 by W. W. Norton & Company, Inc. GLUCOSE-STORAGE 18 Copyright © 2023 by W. W. Norton & Company, Inc. Chapter 14 Energy Generation in Mitochondria and Chloroplasts NADH DONATES HIGH-ENERGY ELECTRONS 20 Copyright © 2023 by W. W. Norton & Company, Inc. ELECTRONS FLOW FROM CARRIER TO OXYGEN 21 Copyright © 2023 by W. W. Norton & Company, Inc. CITRIC ACID CYCLE POWERS ATP-PRODUCTION 22 Copyright © 2023 by W. W. Norton & Company, Inc. ENERGY IS CONVERTED DURING ATP-PRODUCTION 23 Copyright © 2023 by W. W. Norton & Company, Inc. ELECTRON TRANSFER IN INNER MEMBRANE 24 Copyright © 2023 by W. W. Norton & Company, Inc. ELECTROCHEMICAL H+-GRADIENT 25 Copyright © 2023 by W. W. Norton & Company, Inc. ATP SYNTHASE 26 Copyright © 2023 by W. W. Norton & Company, Inc. TWO-WAY FUNCTION OF ATP-STYNTHASE 27 Copyright © 2023 by W. W. Norton & Company, Inc. ATP TRANSPORT OUTSIDE MITOCHONDRIA 28 Copyright © 2023 by W. W. Norton & Company, Inc.  29 Copyright © 2023 by W. W. Norton & Company, Inc. LEARNING OBJECTIVES After attending this lecture, you should be able to… … describe how cells obtain high-energy molecules from the breakdown of food … know the function of the starring molecules in this process … understand the contents of the figures, without having to memorize all the details. 30 Link to Clinical Chemistry GASSES IN BLOOD 32 Chegg.com BLOOD PH (1/2) 33 Bioninja.com BLOOD PH (2/2) 34 Adobe Stock Photo BLOOD GLUCOSE 35 Shalomeducation.com; Emedihealth.com UREA IN BLOOD 36 Osmosis.org CREATININE AS MEASURE OF KIDNEY FUNCTION 37 National Kidney Foundation, Medicine.net THE SODIUM-POTASSIUM PUMP MAINTENANCE OF ELECTROCHEMICAL GRADIENT 38 Copyright © 2023 by W. W. Norton & Company, Inc. LACTATE AS MEASURE OF METABOLIC ACTIVITY 39 Osmosis.org SIDE STEP; IMMUNE RESPONSE AND BLOOD CELLS 40 ScienceDirect.com, Creative Diagnostics, Harvard Medical School CLINICAL CHEMISTRY IS A UNIQUE RESEARCH FIELD!  Guest lecture by Dr. Hans Krabbe, Clinical Chemist, MST  …after the break… 41