Regulation of Body Temperature PDF

# Introduction ## What is physiology? * It is a science concerned with studying: 1. Functions of different body systems. 2. How they perform their functions. 3. Factors affecting their functions. The human body consists of a number of **systems**, each system is formed of **organs**,...

# Introduction ## What is physiology? * It is a science concerned with studying: 1. Functions of different body systems. 2. How they perform their functions. 3. Factors affecting their functions. The human body consists of a number of **systems**, each system is formed of **organs**, each organ is formed of **tissues** and each tissue is formed of **cells** which is the structural unit of the body. Systems -> organs -> tissues -> cells ## The cell: * Composed of a cell membrane and cytoplasm. * Inside the **cytoplasm** there is: * **Nucleus:** which contain the genetic material (DNA). * **Mitochondria:** responsible for energy production inside the cell. * **Golgi apparatus**. * **Lysosomes:** containing proteolytic enzymes * **Ribosomes:** responsible for protein synthesis. * **Centrosome:** responsible for cell division. * Rough and smooth endoplasmic reticulum. # Regulation of Body Temperature ## Introduction Living organisms are classified into two groups, depending upon the maintenance (regulation) of body temperature: 1. **Homeothermic animals** 2. **Poikilothermic animals**. ## Homeothermic (Warm Blooded) Animals Homeothermic animals are the animals in which the body temperature is maintained at a constant level, irrespective of the environmental temperature. Birds and mammals including man belong to this category. They are also called warm blooded animals. ## Poikilothermic (Cold Blooded) Animals Poikilothermic animals are the animals in which the body temperature is not constant. It varies according to the environmental temperature. Amphibians and reptiles are the poikilothermic animals. These animals are also called cold blooded animals. ## Body Temperature Measurement: Body temperature can be measured by placing the clinical thermometer in different parts of the body such as: 1. Mouth (oral temperature) 2. Axilla (axillary temperature) 3. Rectum (rectal temperature) ## Normal Body Temperature Normal body temperature in human is 37°C (98.6°F), when measured by placing the clinical thermometer in the mouth (oral temperature). It varies between 35.8°C and 37.3°C (96.4°F and 99.1°F). ## Temperature at Different Parts of the Body Axillary temperature is 0.3°C to 0.6°C (0.5°F to 1°F) lower than the oral temperature. The rectal temperature is 0.3°C to 0.6°C (0.5°F to 1°F) higher than oral temperature. # Physiological Variations 1. **Age** In infants, the body temperature varies in accordance to environmental temperature for the first few days after birth. It is because the temperature regulating syste does not function properly during infancy. In children, the temperature is slightly (0.5°C) more than in adults because of more physical activities. In old age, since the heat production is less, the body temperature decreases slightly. 2. **Sex** In females, the body temperature is less because of low basal metabolic rate, when compared to that of males. During menstrual phase it decreases slightly. 3. **Diurnal variation** In early morning, the temperature is 1°C less. In the afternoon, it reaches the maximum (about 1°C more than normal). 4. **After meals** The body temperature rises slightly (0.5°C) after meals 5. **Exercise** During exercise, the temperature raises due to production of heat in muscles. 6. **Sleep** During sleep, the body temperature decreases by 0.5°C. 7. **Emotion** During emotional conditions, the body temperature increases. 8. **Menstrual cycle** In females, immediately after ovulation, the temperature rises (0.5°C to 1°C) sharply. ## Pathological variation: Abnormal increase in body temperature is called **hyperthermia** or **fever** and decreased body temperature is called **hypothermia**. # Heat Balance Regulation of body temperature depends upon the balance between heat produced in the body and the heat lost from the body. ## Heat Gain or Heat Production in the Body Various mechanisms involved in heat production in the body are: 1. **Metabolic Activities** Major portion of heat produced in the body is due to the metabolism of food stuffs. It is called **heat of metabolism**. Heat production is more during metabolism of fat. About 9 calories of heat is produced during metabolism of fats. carbohydrate metabolism produces 4.7 calories of heat. Protein metabolism produces 4.5 calories/L. 2. **Muscular Activity** Heat is produced in the **muscle** both at rest and during activities. During rest, heat is produced by **muscle tone**. Heat produced during muscular activity is called **heat of activity**. About 80% of heat of activity is produced by skeletal muscles. 3. **Role of Hormones** Thyroxin and adrenaline increase the heat production by accelerating the metabolic activities. 4. **Radiation of Heat from the Environment** Body gains heat by radiation. It occurs when the environmental temperature is higher than the body temperature. 5. **Shivering** Shivering refers to shaking of the body caused by rapid involuntary contraction or twitching of the muscles as during exposure to cold. Shivering is a compensatory physiological mechanism in the body, during which enormous heat is produced. 6. **Brown Fat Tissue** Brown adipose tissue is one of the two types of adipose tissues, the other being white adipose tissue. ## Heat Loss: Maximum heat is lost from the body through skin and small amount of heat is lost through respiratory system, kidney and GI tract. When environmental temperature is less than body temperature, heat is lost from the body. Heat loss occurs by the following methods: 1. **Conduction** Three percent of heat is lost from the surface of the body to other objects such as chair or bed, by means of conduction. 2. **Radiation** Sixty percent of heat is lost by means of radiation, i.e. transfer of heat by infrared electromagnetic radiation from body to other objects through the surrounding air. 3. **Convection** Fifteen percent of heat is lost from body to the air by convection. First the heat is conducted to the air surrounding the body and then carried away by air currents, i.e. convection. 4. **Evaporation - Insensible Perspiration** When water evaporates, heat is lost. Twenty two percent of heat is lost through evaporation of water. Normally, a small quantity of water is continuously evaporated from skin and lungs. We are not aware of it. So it is called the insensible perspiration or insensible 5. **Panting** Panting is the rapid shallow breathing, associated with dribbling of more saliva. In some animals like dogs which do not have sweat glands, heat is lost by evaporation of water from lungs and saliva by means of panting. # Body Temperature Regulation Body temperature is regulated by the hypothalamus, which sets the normal range of body temperature. The set point under normal physiological conditions is 37°C. Hypothalamus has two centers which regulate the body temperature: 1. Heat loss center 2. Heat gain center. ## Heat Loss Center Heat loss center is situated in **preoptic nucleus of anterior hypothalamus**. Neurons in preoptic nucleus are heat sensitive nerve cells, which are called **thermoreceptor**. Stimulation of preoptic nucleus results in cutaneous vasodilatation and sweating. Removal or lesion of this nucleus increases the body temperature. ## Heat Gain Center Heat gain is otherwise known as heat production center. It is situated in **posterior hypothalamic nucleus**. Stimulation of posterior hypothalamic nucleus cause shivering. The removal or lesion of this nucleus leads to fall in body temperature. # Mechanism of Temperature Regulation When Body Temperature Increases blood temperature also increases. Which when passes through hypothalamus, it stimulates the thermo receptors present in the heat loss center in pre optic nucleus. Now, the heat loss center brings the temperature back to normal by two mechanisms: 1. Promotion of heat loss 2. Prevention of heat production. ## 1. Promotion of heat loss When body temperature increases, heat loss center promotes heat loss from the body by two ways: i. By increasing the secretion of sweat: When sweat secretion increases, more water is lost from skin along with heat ii. By inhibiting sympathetic centers in posterior hypothalamus: This causes cutaneous vasodilatation. Now, the blood flow through skin increases causing excess sweating. ## 2. Prevention of heat production Heat loss center prevents heat production in the body by inhibiting mechanisms involved in heat production, such as shivering and chemical (metabolic) reactions. When the body temperature decreases, it is brought back to normal by two mechanisms: 1. Prevention of heat loss 2. Promotion of heat production. ## 1. Prevention of heat loss When body temperature decreases, sympathetic centers in posterior hypothalamus cause cutaneous vasoconstriction. This leads to decrease in blood flow to skin and so the heat loss is prevented. ## 2. Promotion of heat production Heat production is promoted by two ways: i. Shivering: When body temperature is low, the heat gain center stimulates the primary motor center for shivering, situated in posterior hypothalamus near the wall of the III ventricle and shivering occurs. During shivering, enormous heat is produced because of severe muscular activities. ii. Increased metabolic reactions: Sympathetic centers, which are activated by heat gain center, stimulate secretion of adrenaline and noradrenaline. # Diagram of Heat Regulation Normal body temperature - **Decrease in body temperature** - Stimulation of heat gain center (Posterior hypothalamus) -Increase in sympathetic activity -Shivering -Increased adrenaline secretion and metabolic rate -Cutaneous vasoconstriction and decreased sweating -Decrease in heat loss -Increase in heat production - **Increase in body temperature** - Stimulation of heat loss center (Anterior hypothalamus) -No shivering -Inhibition of sympathetic activity -Decreased adrenaline secretion and metabolic rate -Cutaneous vasodilation and increased sweating -Decrease in heat production -Increase in heat loss Normal body temperature