Pharm Final Drug Chart PDF

c airec : Gq ↑1P3 + DAG 2nd messengers sympathetic...

c airec : Gq ↑1P3 + DAG 2nd messengers sympathetic * protein kinase C Medulla / ppeg.mg/ionic:AChtNicl- Ganglionic neuron Drug Adrenergic Drugs Receptor Target Therapy use Mechanism Adverse effects Contraindications 1: I I Dopamine D1 - Hypovolemic shock - Vasodilation of renal - Delayed diuresis in - Hypovolemia must 1 ' I ⑧ TO - Cardiogenic shock - Oliguric patients blood flow AGER cats - Extraversion of be corrected first - Avoid in patients É MYLEENE O BI Low urine output dopamine receiving MAO × inhibitors or Bi ionotropicefren to Ya caraogeniccontractbicocannoterrea tricyclic ✗ Al vasoconstriction Bv - [ Hypertensive crisis ] antidepressants BSB Fenoldopam D1 - Uses Gs proteins to vsend Methoxamine Dopaminedenvan ongunipatents cause vasodilation 96Frua vasodilation Alpha 1 agonist I - Hypotension during ] - Vasodilation - Hypertensive ' ' surgery * asoconstrictioh headache IV 1M - Vomiting. reffaucaran Metaraminol Alpha 1 agonist I - Hypotension during ] - Vasodilation ' - Hypertensive ± ✗ 1- surgery spinal headache. Va constriction 11M IM 5C - Vomiting. / TQ/ Phenylephrine Alpha 1 agonist - Nasal congestion - Vasoconstriction of TQ I - Glaucoma - Hypotension nasal blood vessels pupildit.-. Mydriatic agent radialmuscles aon IV 1145£ ' Drops / Mist. Orin's contraction - Vasoconstriction vasopressin agent Phenypropanolamine Alpha 1 agonist - [ Urinary incontinenceI.- Urinary sphincter ✗ I PROIN ka po muscle contraction Oxymetazoline Alpha 1 agonist - [ Nasal congestion ].- Vasoconstriction of mesnifftheoxy (partial alpha 2 nasal blood vessels Drops / Mist agonist) I 1 Clonidine Alpha 2 agonist - hypertension - Suppresses outflow of - Dry mouth, sedation, -0 ↓ sympathetic NS by - Preoperative rebound hypertension er release rearegaineobau.ve Ake. Indirect antagonist decreased NE release ↓ Chloegave sedation/analgesia hypertension, sexual dysfunction, sejarnefreaowiane PO menoerection renamooarrownoteffected bradycardia Apraclonidine Alpha 2 agonist - [ Glaucoma ? - Reduces aqueous I aria vasoconstriction ✗ 2 batretinaTO snignpressureineae humor production to relieve intraocular Drops pressure Xylazine Alpha 2 agonist - [ Anesthetic premeds] - Activates alpha 2A - Bradycardia Activatespulmonary subtype receptor in :- Conduction intravascularmacrophages inlargeanimals locus coeruleus of disturbancesDemetri in sheep themene brainstem and SC = - Myocardial a cats acuteLunginjury IV IM Se PO less synthesis and release of NE ↓ , depression Ned Detomidine Alpha 2 agonist [ - Large animal sedation and anesethesia ] - Combined with butorphanol and analgesia sedation I + Analgesic IV Debt add moredrugs mannone ketamine general anesthesia Medetomidine Alpha 2 agonist [ - emergence delirium ] - sedative to calm. Analgesic _ N after anesthesia animal 99 9 Sympathetic peripheral Equine small anim. 1- neinswianxietupostop release  I 4 MY Gi bats live parasympathetic [ § Dexmedetomidine Alpha 2 agonist - emergence delirium - sedative to calm dextroseisomer after anesthesia in animal dexdomitor µ dogs 1- cats x2potencyddon / Romifidine Alpha 2 agonist - emergence delirium - sedative to calm after anesthesia in animal IV horses Methyl DOPA Alpha 2 agonist - [ Hypertension] - Binds to alpha 2 to clokhnidine inhibit NE release ↓ h similar to Kadir.ec/- antagonist - Competitive inhibitor Chloemetanypd of DOPA decarboxylase decarboxylase to dopeboy indirectantagonist feats reduce dopamine synthesis hypotensionprecursor forNE te [ ] Isoproterenol Non-selective ß - bradycardia/heart - inotropic, - palpitations, * q isoprenaline Non Set-. agonist block chronotropic, B , tachycardia, headache n gypsy dromotropic effects - Cardiac ischemia only X B 1kV I'M SC HCl intracardiac) - vasodilation and forcuttocomeoutd uterine relaxation Biz - arrhythmias ✗ , www.nygnyyg - [ Cardiac failure ] OVA Dopexamine ß non-selective - Inotropic agent Bi - MffDobutamine - punumireaem.JO receptors Agonist Bloodnotpumpingtoorgan [ ] ß1 agonist - congestive heart - inotropic agent B- - increases AV atrial fibrillation tacttettitiontaintonTO - ☒ 1311 failure , conduction : strenatnorantraum #☒ 1- rhythm NOT changed! µ www.carawmuome - build tolerance Tachyphylaxis * i. Metaproterenol/orciprenaline ß2 agonist PO Inhalation - [ acute asthma] - bronchodilation Terbutaline ß2 agonist - [ acute asthma] - bronchodilation *- can induce - × not for animals tachycardia with heart disease, EVS teratachucaracaithogygh - higher risk of 9$ hyperthyroidism, 5C PO knhialatioh arrhythmia Terb Turbulence hypertension neat wi 1 I Salbuterol maboatamol ß2 agonist - acute asthma (for - bronchodilation PO Aerosol small animals) named Clenbuterol horse ß2 agonist - [ COPD in horses CLE # ] - Bronchodilation - Banned in foo * a " " producing animalsstifesiave 13£ IN PO GlennhasCOPD Salmeterol Sai slow ß2 agonist achronconstructupumaramainan - [ Chronic asthma] - Bronchodilation, slow performance e nhancement childhood friendhad onset, long acting - Combined with asthma dretorice fluticasone softer Dry Inhalation Powder. (corticosteroid) ] ✓ Isoxuprine Socks laminitisß2 agonist [ - Laminitis - Vasodilator to skeletal " TQ ' " Sox IningQPO Powder to Feed Navicular disease muscles improvesbloodsupply Ritodrine Ritaneedsto ß2 agonist - [ Premature labor I - - Tocolytic agent = NV thebaby keep preventlabor uterine relaxant [ ] ✓ Rackthe Ractopamine ß2 agonist - Repartitioning agent - No pre-slaughter - Bloat * weights cattle + swine withdrawal - Anorexia * 361T Disorders TQ ✓ improves leanness in B- ovine swine - Locomotion disorder × Palm Edema skel.vn tremors downregulation chronic use ( tolerance / tachyphylaxis) Bz agonist SE : Tachycardia ,. ,. ,  MISCELLANEOUS ADRENERGIC trancouanotreceasehimair blousedcondom """ " " " "± "" " " " " ° " " """ % " "" " "" [ ① " " " """ "" ° " " " " " " """ "" " "* " "" " " "" NE " from " " Mixed agonist ß2 - Asthma - Bronchodilation B2 - ◦ Mixed agonist alpha - Hypotension during - Vasoconstriction ⑧ - * Hypertension 1 spinal anesthesia - Increase urinary * , o - * Cardiac arrhythmias Ephedrine - Nasal congestionincats sphincter contraction - Insomnia * BBM - Urinary incontinence - Tachyphylaxis * Mixed agonist - Myasthenia gravis - - Increases Ach in - nicotinic receptors a norveriananoai autoimmune synapse = more N PO Nasaildrops inuntomvanconnecrea binding to receptors musuewearnessornavansis Reserpine Indirect antagonist - [ Tranquilizer in horses] - Interferes with i storage of NE by decreases thereserves inhibiting presynaptic to transporter protein = ti $1M Long acting attendantlearn reduced NE uptake { - Phenoxybenzamine Non-selective alpha - Pheochromocytoma - Prevents o - Postural hypotension ✗ - EPINEPHRINE 0 benisanalpha antagonist hypertension - Benign prostatic s vasoconstriction - Relaxes urinary - ✗ Nasal congestion nausea urananationornasaimuaresse - Inhibit ejaculation REVERSAL = slight rise in BP q ✗ BRM for ◦ thestreets irreversible obstruction hitter sphincter and - Aspermia vomit ☒zsbinoshere na × prostate a m - Detrusor areflexia prostate gland - Reflex tachycardia k nagging *- Mutagenic nature boma m PO ka wannabe Feline cockfights ↑ aww CO sunapticreceptorony when used long-term Iacigrgannomas now 1. r Phenolamine Non-selective alpha - Pheochromocytoma * - vasodilation - Postural hypotension × Pihento/ amine I outtalk't antagonist hypertension ✓ - improves GI motility - Reflex tachycardia * - Pseudo-obstruction of - Stops vasoconstriction - Arrythmias = × oraverse intraoral sub- mucosal bladderbowel to site of alpha - Diarrhea ✗ cause'omotiity injection - Prevent dermal ✓ agonist extraversion absorption epinephrine necrosiscoraverse - Improves blood allows Poor 61vasodilation reverse oral localanesthetic - reverse oral local ii supply to site of oral e to diffuse IV 114 I bloodsupply Antidote for : b anesthetic blocking out - f Reverse effects of II. Tolazoline Non-selective alpha - -. Blocks alpha 2 agonist - Cardiac arrhythmias × antagonist A'* for : xylazine in large effects of xylazine - GI stimulation = pain,, * sounds live i animals - Vasodilation I'Éasoconsmannausea,$ exacerbation i s 44112in exacutoazhisner - Arteriography - Pulmonary of ulcer of hypertension of animals ones A Prazosin (Related = Terazosin, Alpha 1 antagonist newborns - Hypertension ✓ - Vasodilator - Dizziness reflex less tachycardia ' antagonist ginning doxazosin, tamsulosin) - Mild heart failure - Diuretic agent = relax - Nasal congestion selective ' significant TQ - Benign prostate urinary sphincter - Headache J baa navailable X - PO hypertrophy d - Less sedation caused - Drowsiness. - Orthostatic I 1 Tamsulosin (derivative of Alpha 1 antagonist - Benign prostate - Increases urinary ✓ 1 Prazosin)antagonist hypertrophy output by relaxing hypotension detective "° Yohimbine Alpha 2 antagonist - Kidney stones - Reversal agent of urinary sphincter - Blocks alpha 2 more selective torunnamtract IN nouthimbine now antagonistan thehorse Yono selective d 1 xylazine and detomidine in large animals I receptors in brain = more NE released ↑ @ synaptic cleft ✗I Tolazoline reverses ✗Horine in ↳ ' animals Yohimbiue Pheutolamine EP reversal : or ; Phenixybenzamine or Antony.  { ) Atipamezole Alpha 2 antagonist - Reversal agent of - Blocks alpha 2 " dexmedetomidine receptors in brain = Anti sedan Sdective and medetomidine in more NE released ↑ 1M naiveincollapse dogs. P Propranolol Non-selective ß - [ Heart arrythmias ] - Negative inotropic i ×- Bronchoconstriction antagonist associatedw nigh and chronotropic - Cardiac arrhythmias if S ✗ levelsofcatecholamines effect B ofreceptors sudden stopsavetorreguation to slowseratetanows bioratoreautrinneto - Peripheral ' Ba ✗- Hypoglycemia eep Bpiminwin bodywarmutumia vasoconstriction p h - Bronchoconstriction i Beth - Increase Na+ retentionavettoer antagonist - Decrease glucose r metabolismmaritime manami - Sedation / anxiety - Non - Set T Timolol unmentateosonansereau Non-selective ß antagonist - [ Wide angle glaucoma] - Decrease aqueous. humor production to important. B decrease intraocular Drops Bitonantagonist Antag pressure antrasoconstiain s. Sotalol Non-selective ß - [ Arrhythmias] - Modulates K+ V PO antagonist [ventriculi tachycard Dogs ]. channels / / Atenolol ß1 antagonist - Hypertension Acebutolol ß1 antagonist - Ischemic heart B1 Metoprolol ß1 antagonist disease ☒ #☒ Antag. mmmm.it IEfapressucrmncaiemol IEEMintionary - Thyrotoxicosis - Pheochromocytoma Iif - Esmolol iii y ß1 antagonist I - Best for heart attack conditions 1 ultrashortacting manatagonist Therapeutic use of Nonselective B- blockers: : cardiac arrhythmias , Glaucoma bronchoconstriction 13Blower E ionotrophi chnnotrophic ifmainissueisMortoprevent lot XUPt PTS  Parasympathetic Pre ganglionic Acht Nic Ganglionic neurons Parasympatlaomimetic + ↑kᵗ : Indications : µ, : inhibit adenylyl cyclase > postganglionic : Acht Muscarinic Cholinergic Drugs , , bladder m atony GI paralytic ileus Urinary. , , M* , }, s : ⑤q Phospholipids Impaction Colic , Glaucoma began Drug Receptor/Target Therapy use Mechanism Adverse effects Contraindications Acetylcholine Muscarinic and Parasympathetic stimulation - Receptors on vascular ↑ GIT motility / secret. Nicotinic agonist endothelium = induce NO release = cGMP Broncho constriction Ach Ach vasodilation Ach - Negative chronotropic : and inotropic effect - Slows ventricular rate Carbachol Nicotinic and - Rumen atony - - Increase GI motility i - For GI impactions = muscarinic agonist ¥ - Impaction colic - Miosis = drain aqueous attempt mineral oils - Glaucoma in dogs humor = reduce or laxatives first 8 ¥É Direct parasympathomimeitic Drops intraocular pressure baconobememannaimn 11 Bethanechol 14114,1 When BethaneTQ Muscarinic agonist ✓ - GI paralytic ileus No obstruction - Increase GI motility ✓ - Bladder muscle atony - Increase urine output - Mechanical obstruction in GI can PO Direct p herbladderconstants sympathomimetic nocutraction females by improving bladder tone - cause rupture Pregnancy = higher risk of abortion ii iiw mini Pilocarpine M3 agonist ✓ - Chronic and acute glaucoma - Contraction of in dogs sphincter of iris and gg Naturally occurrin wantto Drops cry Parasympathomimetiic - Keratoconjunctivitis sicca 6dm ciliary muscle of lens - Increase tear production Physostigmine Reversible AchE ✓ - Glaucoma - Combines with AchE - Large dose = * - Synergistic effect × Auramine inhibitor reversal : - Antidote for atropine toxicity - GI impaction in cattle inhibits hydrolysis of Ach stimulation then depression of with drugs metabolized by ChE admiring - myanaswiatonne - Prolongs action of Ach CNS or other AChE Tessimponent - Permeates blood brain - Massive dose = ✗ inhibitors barrier = CNS effect convulsion - Debilitated animals ✗ It Neostigmine Reversible AchE ✓ sannboalesbanotonic - Myasthenia gravis Neo Non reap ✓- Prolongs Ach actions - - Skeletal muscle × - Hepatic diseases × Gacnamine inhibitor *- Nm ✓ - Reverse non-depolarizing Nm ✓ - Increases muscle weakness if (lower AChE d agonist blocking contractions toxicology synthesis) neuromuscular man Anti curare - - ✗ If use depolarizing Nm - ✗ Respiratory illness - Pregnancy ✗ m amongp PO www.ma.mn 7- blocking agent = mmmm annauerrampiremioting reveries this pig risk of toxicity Edrophonium YtkYietd Reversible AchE f tanttcura - Anti-curare reverse non denouncing b - Interacts with anionic - Bradycardia × ummmday short.tt inhibitor - Diagnosis of myasthenia and esteratic sides of ye ed gravis AchE alldo gymm Short ac - Short duration of yyy ✓ action / ] Pyridostigmine Reversible AchE - Myasthenia gravis - Prolongs Ach actions on Nic rel I Auramine inhibitor - Increases muscle Giant Anti curare - ↳ Ong acting contractions getrdor fOF 70 thisdose selective to Nicrec for NMB inhibition Inhibitor contraindications. nominating longacting preferredfor Reversible Ch # : f-arasyimpathiormimetiic SE : Impaction , Pregnancy myastheniagrans Broncho constriction , Bradycardia , Uterus contractions ( abortion) Nm effects , , CNS effects vomit diarrhea urin.in cont Prttlidoxivhe Salivation , Sweating. Miosis. CHIÉ reactivation , , : , ,  Antimuscariuic Autonomic Ganglionic Blockers : Nicotinic effect of Ach Anti muscarinic contraiud : Use : antispasmodic , antagonize anti secretory ( adjunct to - anesth ) Ax Atropine. tox ;. Trimet ☒ phan / short-acting -. competitive lowers Emergency Hypertension). ↑ intraocular pressure , , , motion silkne Nicotine antagonist compenne. examethonium acnbingsegth Organophosphorus Irreversible AchE - Caused by poisoning - Irreversibly - ☆ Profuse MUST USE ATROPINE AND compounds inhibitors d organophosphorus phosphorylates esteratic site of AChE salivation, vomiting, GI = PRRALIDOXIME IMMEDIATLEY TO REVERSE and hypermotility ACTIONS pseudocholinesterase - ✗ Defecation - ✗ Bradycardia ✗ - Hypotension Indirect cholinergic - * Muscle twitching agonist - ✗ Muscle paralysis - ✗ Convulsions Pralidoxime ✓Phosphorylated A - Organophosphorus ✓ - Removes PO4 group - Cannot use with * I tester's't esteratic site of compound poisoning from enzyme oximes ftp.fnig IN Atropine AchE Muscarinic ✓ uactetoxity - Everything that involves the % - Reactivates AchE - Literally all the inserts Tachycardia ✗ Glaucoma ✗ - Intraocular pressure Toxicity in : antagonist parasympathetic system parasympathetic ↑ BP - ¥ anone Rabbits are resistant Phiysostigmine ↓ quaggy urin retention , zijn. - Antidote for cholinergic pathways mascannacreonVagolyytiic Herbivores less sensitive ☒ eostigmine effects Parasynnpatholytic agonists Atropine aqu humor.. Broncho dilation ↓ secretions Relax 0.1 ↓ secretions Ahhhidrotic , Mydriasis disasweating innergaman. ✓ Scopolamine Muscarinic - Motion sickness - Slight sedation Does not cross BBB / manilius = seminars synthetic antagonist ✓ - Antiemetic sty Pirenzepine FIIaninentasemnonitoreen Muscarinic antagonist ✓ - Reduce gastric secretions ✓ - Block parasymp stimulation Tropicamide Muscarinic ✓ - Adhesion between iris and it - Mydriatic and opthalmic g antagonist lens ocular synechia cycloplegic agent :* j Glycopyrrolate Muscarinic ✓ - Preanesthetic ✓ - Potent antimuscarinic ÷ Fortosiigin antagonist asecretions - Longer duration than less lipophilic rusx ✓ atropine - Good atropine substitute Homatropine Muscarinic ✓ - Mydriatic and cycloplegic it - Reduce parasymp TTnthetpic same antagonist agent optic effects - Shorter duration than Drops exreaastmam safe drug atropine 91 ✓ § Ipratropium Muscarinic - Chronic asthma - Bronchodilation Nasal Spray Nasal Spray assistant antagonist