Drug Chart for Obesity PDF

Brand/Gener Class ic XENICAL Lipase orlistat Inhibitor Phentermine IR + Topiramate ER Sympatho mime7c/ an7epilep7 c (Topiramate) drops levels of phentermine for long term MOA Decreases intes7nal fat absorp7on by inhibi7ng pancrea7c and intes7nal lipase ac7vity by directly binding to the lipase...

Brand/Gener Class ic XENICAL Lipase orlistat Inhibitor Phentermine IR + Topiramate ER Sympatho mime7c/ an7epilep7 c (Topiramate) drops levels of phentermine for long term MOA Decreases intes7nal fat absorp7on by inhibi7ng pancrea7c and intes7nal lipase ac7vity by directly binding to the lipase GI: oily rectal leakage, abdominal distress, abdominal pain, flatulence with discharge, bowel urgency, steatorrhea, Prevents triglyceride oily evacua7on, breakdown to frequent bowel monoglyceride for movements, nausea, absorp7on into circula7on fecal incon7nence Sympathomime7c amine/adrenergic agonist; Sympathomime7c acts as an appe7te suppressant increases energy expenditure. Topiramate blocks sodium channels enhances GABA ac7vity, antagonizes glutamate receptors, weakly inhibits carbonic anhydrase; suppresses appe7te. Makes you feel full Naltrexone/B Opioid upropion antagonist/ dopamine and norepineph rine reuptake inhibitor Reduces cravings. Bupropion enhances POMC cell produc7on and release of alpha MSH and Beta endorphin and suppresses appe7te. Liraglu7de (Saxenda) Ac7vates GLP 1 receptor in the brain, regula7ng appe7te and caloric intake. Increases sa7ety, slows gastric emptying GLP -1 agonist ADRs Together they work on the hypothalamus and mesolimbic dopamine circuit Tachycardia, paresthesia, headache, insomnia, decreased serum bicarbonate, xerostomia, cons7pa7on, URTI nasopharyngi7s, dysgeusia, dry mouth Others: Dizziness, depression, anxiety, cogni7ve dysfunc7on, irritability, hypokalemia, increased thirst, hypoglycemia in DM Headache, sleep disorder, nausea, vomi7ng, cons7pa7on, diarrhea, dry mouth, insomnia, dizziness HTN, palpita7ons, depression, hyperhidrosis, diarrhea, UTI, hot flashes GI: nausea, diarrhea, cons7pa7on, vomi7ng, abdominal pain dyspepsia, hypoglycemia Contraindica6ons Pregnancy, chronic malabsorp7on syndromes, cholestasis Cau7on hepatoxicity, hyperoxaluria, calcium oxalate, nephrolithiasis, anorexia nervosa, bulimia, organ transplant, increased risk cholelithiasis with substan7al weight loss MAO inhibitor use within 14 days, pregnancy, breasXeeding, hypothyroidism, glaucoma, Cau7on can increase heart rate, cogni7ve dysfunc7on/psychiatric disturbances can occur; associated with acute myopia and secondary angle closure glaucoma Pregnancy, breasXeeding, MAOI within 14 days, ESRD, uncontrolled HTN, seizure disorder/history, bulimia, anorexia Cau7on suicidality, psychiatric disorder, bioplar disorder, acute opioid withdrawal Pregnancy, personal/family history of medullary thyroid carcinoma, mylpitle endocrine neoplasia syndrome type 2 headache, tachycardia Per Lexicomp