NPB 010 Lecture 20 PDF

"/15 NPB 00 Lecture 20 ① In addition to there primary immune sites immune sites. are also s...

"/15 NPB 00 Lecture 20 ① In addition to there primary immune sites immune sites. are also secondary ↳ Here they may encounter pathogen ↳ upon pathogen binding , they activate trash ? 1) Spleen cleans blood of debris E particularly dead cells , red blood cells 2) lymph nodes collection point of immune cells , connected by lymph vessels (similar to reins with values) lymph = clear liquid , derived from blood , but no red blood cells & looks clear  ② 3) tonsils in mouth=> checking food for pathogen 4) adenoids in nose check air 5) Peyer's patches clusters of immune cells in got & Two main branches of immune system (based on how they function) ↳ different cell type e - mechanisms ↳ own advantage/disadvantages  innate ③ First branch= born with in " Through cuolution cells have the ability to aquired recognize Associated Molecular "Pathogen & Patterns" PAMPS y e.. g [ Bacterial cell wall bacterial tail proteins 6 naked DNA (ho proteins associated) innate immune cells have specialized receptors for these "Toll like receptors" ADVANTAGE : ready to acts fast go , => first line of defence  ④ Disadvantage : because it does Does not not improve, remember Second Branch Adaptive/ acquired immune system Acts more slowly (the first time seeing a new pathogen) recognize a small piece of protein acids &mount -camino a response AUTIGEN The cells bind tightly & improve time binding over Cells of the immune ⑤ system. granulocytes First group ↳ granule-filled cells have poison , messages granules can for other immune cells. A neutrophilic granulocyte most common they can do phagocytosis u I wrap around cell & then (engulf) it another destroy granules of ⑥ immune ↑ 8 activebacterium z b substance & * * 8 - o * · & g O I 8 & / *↳ & Ntne j * & b piece of bacterium Net is shown to dimmune Tall system · = MH = Major * histocompatibility complex # ↳ bacteria  ⑰ B) Eosinophil secretes chemicals to kill large parasites (too big to phagocytose) c) Basophil-secretes histamine Histamine causes vasodilation 14 blood comes in more , bringing other immune cells- In anaphylactic shock : too much histamine - BP everywhere ly epinephrin & to counter the BP drop we inject , a. K. a. adrenalin to vasoconstric