LIFE 207 PK Lecture 2 Oral Absorption & Hepatic Clearance PDF
Document Details
University of Liverpool
Shampa Das
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Summary
This lecture covers oral absorption and hepatic clearance, including key concepts in pharmacokinetics (PK). It discusses bioavailability and factors influencing drug exposure. The lecture notes also include formulas and graphs.
Full Transcript
LIFE 207 – Oral absorption and Hepatic clearance Lecture 2 Shampa Das [email protected] 1 Attendance code Please record your attendance before the end of the lecture 2 Recap What we...
LIFE 207 – Oral absorption and Hepatic clearance Lecture 2 Shampa Das [email protected] 1 Attendance code Please record your attendance before the end of the lecture 2 Recap What we mean by pharmacokinetics (PK)? How we use PK to link dose to exposure and response: Select and optimise dose Processes which influence drug exposure: ADME Key PK parameters: Exposure: AUC, Cmax, Tmax, Cmin Derived parameters: CL, V, t1/2 0.693 𝐴 0.693 × 𝑉 t 1/2= 𝑉= 𝐶𝐿= 𝑘 𝐶 t 1/2 3 Today’s lecture Oral absorption Hepatic clearance 4 Drug Absorption Oral administration Dose of Drug Administered Influenced by: Physico-chemical properties of Bioavailability – Fraction of drug unchanged drug reaching Metabolism systemic circulation after administration Transporters Food Intravenous (IV) Drug administration – drug Concentration directly into blood in Systemic Circulation (no absorption) = 100% bioavailable Bioavailability – F Intravenous - F=1 Drug Oral administration often F
