L17 PDF: Gene Expression Notes

(General Transcription Factors) E denotes the Enhancer and P denotes the Promoter The wording in lecture was different , but the points were the same TFs/GTF interaction allows EnhancerPromoter Loop formation You can imagine how disastrous it can be if transcribed incorrectly, leading to consequence...

(General Transcription Factors) E denotes the Enhancer and P denotes the Promoter The wording in lecture was different , but the points were the same TFs/GTF interaction allows EnhancerPromoter Loop formation You can imagine how disastrous it can be if transcribed incorrectly, leading to consequences down the line! Gene/Protein Making thousands of different enhancer-promoter loops! Webbing between digits is the embroyonic state in humans, but mistakes in the formation of the BMP4 Enhancer-Promoter Loop can lead to some humans having some webbing between digits, because webbing cells are not triggered to die. For example, in kidney development only kidney enhancer-promoter loop forms (not the nose or webbing enhancer-promoter loop) There are regions upstream and downstream from the gene body not involved in transcription, which will be named in the next slide) DNA is a Mosaic of different regions! 7methyl Guanine is the simplest 5’-cap and is covalently bonded to three phosphates. (There are more complex 5’ caps.) Spliceosome remove introns leaving behind exons and a little bit of the 3’ end! The 3’ end is removed and a polyA tail is added. A UTR (Untranslated Region) is present upstream and downtream from the translated region