Immunofluorescence Findings in Rapidly Progressive Glomerulonephritis PDF

## Table 12.1: Immunofluorescence Findings in Rapidly Progressive Glomerulonephritis | IMMUNOFLUORESCENCE PATTERN | DISEASE | COMMENTS | |:---|:---|:---| | Linear (anti-basement membrane antibody, Fig. 12.15) | Goodpasture syndrome | Antibody against collagen in glomerular and alveolar basement mem...

## Table 12.1: Immunofluorescence Findings in Rapidly Progressive Glomerulonephritis | IMMUNOFLUORESCENCE PATTERN | DISEASE | COMMENTS | |:---|:---|:---| | Linear (anti-basement membrane antibody, Fig. 12.15) | Goodpasture syndrome | Antibody against collagen in glomerular and alveolar basement membranes; presents as hematuria and hemoptysis, classically in young, adult males | | Granular (immune complex deposition) | PSGN (most common) or diffuse proliferative glomerulonephritis | Diffuse proliferative glomerulonephritis is due to diffuse antigen-antibody complex deposition, usually sub-endothelial; most common type of renal disease in SLE | | Negative IF (pauci-immune) | Wegener granulomatosis, microscopic polyangiitis, and Churg-Strauss syndrome | Wegener granulomatosis is associated with c-ANCA; microscopic polyangiitis and Churg-Strauss are associated with p-ANCA. Granulomatous inflammation, eosinophilia, and asthma distinguish Churg-Strauss from microscopic polyangiitis. |