Drugs for Movement Disorders Part 3-PDF

**Slide 26 -- COMT Inhibitors** 1. **Which enzyme does COMT inhibitors block to increase the bioavailability of levodopa?** - A\) DOPA decarboxylase - B\) Catechol-O-methyltransferase - C\) Monoamine oxidase B - D\) Tyrosine hydroxylase\ **Answer**: B) Catec...

**Slide 26 -- COMT Inhibitors** 1. **Which enzyme does COMT inhibitors block to increase the bioavailability of levodopa?** - A\) DOPA decarboxylase - B\) Catechol-O-methyltransferase - C\) Monoamine oxidase B - D\) Tyrosine hydroxylase\ **Answer**: B) Catechol-O-methyltransferase 2. **Which of the following is a common side effect of COMT inhibitors?** - A\) Hyperglycemia - B\) Diarrhea - C\) Bradycardia - D\) Insomnia\ **Answer**: B) Diarrhea 3. **Why is tolcapone less commonly used than entacapone?** - A\) Higher risk of hepatotoxicity - B\) Less effective - C\) Causes hallucinations - D\) Poor absorption\ **Answer**: A) Higher risk of hepatotoxicity **Slide 27 -- Adenosine Antagonist** 4. **Istradefylline (Nourianz®) is primarily used to treat which aspect of Parkinson\'s disease?** - A\) Bradykinesia - B\) Tremor - C\) "Off" episodes - D\) Dyskinesia\ **Answer**: C) "Off" episodes 5. **Which receptor does istradefylline antagonize to exert its effects?** - A\) Dopamine D2 - B\) Adenosine A2A - C\) Acetylcholine M1 - D\) NMDA\ **Answer**: B) Adenosine A2A 6. **What is a common side effect of istradefylline?** - A\) Dyskinesia - B\) Bradycardia - C\) Sedation - D\) Hallucinations\ **Answer**: A) Dyskinesia **Slide 28 -- Amantadine** 7. **Amantadine is effective in treating which symptom of Parkinson\'s disease?** - A\) Rigidity - B\) Dyskinesia - C\) Bradykinesia - D\) Postural instability\ **Answer**: B) Dyskinesia 8. **What is the primary mechanism of action of amantadine?** - A\) NMDA receptor blockade - B\) Dopamine receptor agonist - C\) COMT inhibition - D\) Monoamine oxidase B inhibition\ **Answer**: A) NMDA receptor blockade 9. **Which side effect is commonly associated with amantadine?** - A\) Livedo reticularis - B\) Hypoglycemia - C\) Dry mouth - D\) Hyperhidrosis\ **Answer**: A) Livedo reticularis **Slide 29 -- Antimuscarinics** 10. **Which symptom of Parkinson\'s disease are antimuscarinics most effective in treating?** - A\) Tremor - B\) Bradykinesia - C\) Dyskinesia - D\) Rigidity\ **Answer**: A) Tremor 11. **Which of the following is a known side effect of antimuscarinics like benztropine?** - A\) Memory impairment - B\) Hyperglycemia - C\) Weight gain - D\) Bradycardia\ **Answer**: A) Memory impairment 12. **What is the mechanism of action of benztropine in Parkinson's disease?** - A\) Inhibits dopamine reuptake - B\) Inhibits acetylcholine activity - C\) Blocks NMDA receptors - D\) Inhibits serotonin reuptake\ **Answer**: B) Inhibits acetylcholine activity **Slide 30 -- Considerations** 13. **What is a key consideration when initiating levodopa treatment in elderly patients with Parkinson's?** - A\) Start with dopamine agonists - B\) Combine with antipsychotics - C\) Avoid carbidopa/levodopa due to motor complications - D\) Start with a COMT inhibitor\ **Answer**: A) Start with dopamine agonists 14. **Which of the following drugs may worsen Parkinson's symptoms by blocking dopamine receptors?** - A\) Metoclopramide - B\) Clonidine - C\) Propranolol - D\) Diazepam\ **Answer**: A) Metoclopramide 15. **Which approach can help manage motor complications in long-term levodopa therapy?** - A\) Increasing the dose of levodopa - B\) Switching to antimuscarinics - C\) Adding a COMT inhibitor - D\) Adding beta-blockers\ **Answer**: C) Adding a COMT inhibitor **Slide 31 -- Essential Tremor** 16. **Which treatment is first-line for essential tremor?** - A\) Anticholinergics - B\) Beta blockers - C\) Levodopa - D\) MAO-B inhibitors\ **Answer**: B) Beta blockers 17. **Which type of tremor is typically seen in essential tremor?** - A\) Resting tremor - B\) Intention tremor - C\) Postural tremor - D\) Rubral tremor\ **Answer**: B) Intention tremor 18. **Which medication may worsen essential tremor?** - A\) Lithium - B\) Topiramate - C\) Metoprolol - D\) Propranolol\ **Answer**: A) Lithium **Slide 32 -- Beta Blockers for Essential Tremor** 19. **Which beta blocker is most commonly used for essential tremor?** - A\) Atenolol - B\) Propranolol - C\) Metoprolol - D\) Bisoprolol\ **Answer**: B) Propranolol 20. **Which of the following beta blockers can cross the blood-brain barrier, making it more effective for essential tremor?** - A\) Propranolol - B\) Atenolol - C\) Bisoprolol - D\) Metoprolol\ **Answer**: A) Propranolol 21. **What is a potential side effect of beta blockers when treating essential tremor?** - A\) Bradycardia - B\) Insomnia - C\) Hyperglycemia - D\) Constipation\ **Answer**: A) Bradycardia