Drugs for Movement Disorders
101 Questions
1 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What role does acetylcholine play in Parkinson's disease pathogenesis?

  • It blocks NMDA receptors
  • It becomes overactive when dopamine levels drop (correct)
  • It inhibits dopamine production
  • It enhances GABA activity

    • What is the primary effect of dopamine in the basal ganglia?

  • Inhibit cholinergic neurons (correct)
  • Decrease serotonin release
  • Increase GABA release
  • Stimulate cholinergic neurons

    • In Parkinsonism, what happens to the inhibitory pathway of the basal ganglia?

  • It becomes overactive due to serotonin deficiency
  • It becomes underactive due to excessive dopamine
  • It becomes overactive due to dopamine deficiency (correct)
  • It becomes underactive due to acetylcholine excess

    • What symptom arises from an imbalance between dopamine and acetylcholine in Parkinson's disease?

    <p>Tremor</p> Signup and view all the answers

    What neurotransmitter imbalance is critical in Parkinson's disease?

    <p>Dopamine and acetylcholine</p> Signup and view all the answers

    What role does GABA play in the motor dysfunction seen in Parkinsonism?

    <p>GABA becomes overactive due to excess acetylcholine</p> Signup and view all the answers

    How does dopamine deficiency affect GABAergic signaling in Parkinson's disease?

    <p>Increases inhibitory control of muscles</p> Signup and view all the answers

    What is the primary goal of treatment in Parkinsonism?

    <p>Increase dopaminergic neurotransmission</p> Signup and view all the answers

    What is the primary method of action for drugs used in the treatment of Parkinson's disease?

    <p>Enhance dopaminergic neurotransmission</p> Signup and view all the answers

    Which symptom is specifically associated with Parkinsonism and often evaluated in clinical assessments?

    <p>Resting tremor</p> Signup and view all the answers

    Which neurotransmitter imbalance is primarily observed in individuals with Parkinson's disease?

    <p>Deficient dopamine levels</p> Signup and view all the answers

    Which gene mutation is strongly associated with the juvenile form of Parkinson's disease?

    <p>Parkin gene</p> Signup and view all the answers

    In what part of the brain does the neurodegeneration primarily occur in Parkinson's disease?

    <p>Substantia nigra</p> Signup and view all the answers

    What is a common class of medications that can induce symptoms similar to those of Parkinson's disease?

    <p>Antipsychotics</p> Signup and view all the answers

    What age range is most typical for the initial manifestation of Parkinson’s disease symptoms?

    <p>50-60 years</p> Signup and view all the answers

    Which of the following is NOT a common symptom associated with Parkinson's disease?

    <p>Tachycardia</p> Signup and view all the answers

    What is the most common adverse effect experienced by patients undergoing long-term Carbidopa/Levodopa therapy?

    <p>Dyskinesia</p> Signup and view all the answers

    What significant advantage do dopamine agonists offer in treating Parkinson's disease compared to levodopa?

    <p>Lower incidence of dyskinesia</p> Signup and view all the answers

    Which of the following is classified as a dopamine agonist?

    <p>Pramipexole</p> Signup and view all the answers

    In the treatment of Parkinson's disease, dopamine agonists are especially effective in managing which specific symptom?

    <p>On-off phenomena</p> Signup and view all the answers

    What is the mechanism of action of MAO-B inhibitors in the context of treating Parkinson's disease?

    <p>Inhibiting the breakdown of dopamine in the brain</p> Signup and view all the answers

    Which side effect is commonly associated with the use of MAO-B inhibitors?

    <p>Nausea</p> Signup and view all the answers

    Which MAO-B inhibitor is recognized for its potential neuroprotective effects?

    <p>Rasagiline</p> Signup and view all the answers

    Which COMT inhibitor is known to pose a risk of hepatotoxicity?

    <p>Tolcapone</p> Signup and view all the answers

    Which drug class is primarily used to enhance dopamine levels in patients with Parkinson's disease?

    <p>Dopamine agonists</p> Signup and view all the answers

    In Parkinsonism, which neurotransmitter becomes overactive due to a lack of dopamine?

    <p>Acetylcholine</p> Signup and view all the answers

    What role does Carbidopa play in the treatment of Parkinson's disease when used in combination with Levodopa?

    <p>It inhibits the peripheral conversion of levodopa to dopamine</p> Signup and view all the answers

    Which medication acts by inhibiting the enzyme COMT to increase levodopa's availability in the central nervous system?

    <p>Entacapone</p> Signup and view all the answers

    Which dietary component is most likely to hinder the absorption of levodopa?

    <p>High-protein meals</p> Signup and view all the answers

    Which formulation of Carbidopa/Levodopa is specifically designed for on-demand relief of motor fluctuations?

    <p>Inbrija</p> Signup and view all the answers

    In the context of Parkinson's disease treatment, which medication inhibits the breakdown of dopamine?

    <p>Selegiline</p> Signup and view all the answers

    Which Carbidopa/Levodopa formulation is available in an extended-release form?

    <p>Rytary</p> Signup and view all the answers

    Which side effect is most notably linked to prolonged treatment with Carbidopa/Levodopa?

    <p>Dyskinesia</p> Signup and view all the answers

    What strategy can effectively mitigate dyskinesia in individuals being treated with Carbidopa/Levodopa?

    <p>Introducing a dopamine agonist</p> Signup and view all the answers

    Carbidopa/Levodopa is contraindicated in which condition due to increased risk of adverse effects?

    <p>Closed-angle glaucoma</p> Signup and view all the answers

    What is the term for the phenomenon where Levodopa suddenly loses effectiveness without any timing-related explanations?

    <p>On-off phenomenon</p> Signup and view all the answers

    To alleviate the 'wearing-off' effect in patients taking Levodopa, which approach should be considered?

    <p>Increasing the frequency of doses administered</p> Signup and view all the answers

    What is a significant risk that arises from taking a 'drug holiday' with Levodopa therapy?

    <p>Severe immobility as a consequence</p> Signup and view all the answers

    Which dopamine agonist is recognized for its availability as a transdermal patch for treating Parkinson's disease?

    <p>Rotigotine</p> Signup and view all the answers

    What is a widely accepted side effect of dopamine agonists such as Pramipexole and Ropinirole?

    <p>Disruption in impulse control</p> Signup and view all the answers

    What distinguishes rotigotine from other dopamine agonists in terms of its administration method?

    <p>Transdermal patch</p> Signup and view all the answers

    Which dopamine agonist has a mechanism that primarily targets D2 receptors?

    <p>Ropinirole</p> Signup and view all the answers

    At high doses, selegiline may inhibit which of the following enzymes?

    <p>Monoamine oxidase-A</p> Signup and view all the answers

    Which of the following medications is likely to cause sleep attacks as a side effect?

    <p>Pramipexole</p> Signup and view all the answers

    What is the primary target of MAO-B inhibitors in the brain?

    <p>Monoamine oxidase-B</p> Signup and view all the answers

    What is a notable effect of rotigotine that sets it apart from its counterparts?

    <p>Continuous dopaminergic stimulation</p> Signup and view all the answers

    Which side effect is NOT typically associated with rotigotine therapy?

    <p>Blood dyscrasias</p> Signup and view all the answers

    What is a common adverse effect of selegiline, particularly at therapeutic doses?

    <p>Nausea</p> Signup and view all the answers

    Which MAO-B inhibitor is distinguished for both its neuroprotective properties and potency?

    <p>Rasagiline</p> Signup and view all the answers

    What enzyme is specifically targeted by the reversible inhibitor Safinamide?

    <p>Monoamine oxidase-B</p> Signup and view all the answers

    Among the following options, which drug is recognized for its higher potency in comparison to selegiline?

    <p>Rasagiline</p> Signup and view all the answers

    What is a common psychiatric side effect associated with the use of MAO-B inhibitors in Parkinson's disease management?

    <p>Hallucinations</p> Signup and view all the answers

    What is the primary mechanism by which COMT inhibitors contribute to the treatment of Parkinson’s disease?

    <p>Inhibiting peripheral breakdown of levodopa</p> Signup and view all the answers

    Which of the following COMT inhibitors is known to have a significant risk of hepatotoxicity?

    <p>Tolcapone</p> Signup and view all the answers

    What harmless side effect can occur with the use of the COMT inhibitor Entacapone?

    <p>Red-colored urine</p> Signup and view all the answers

    What mechanism does the drug Istradefylline utilize in Parkinson's disease treatment?

    <p>Antagonizes adenosine A2A receptors</p> Signup and view all the answers

    What is the primary function of COMT inhibitors in the treatment of Parkinson's disease?

    <p>Block the breakdown of levodopa</p> Signup and view all the answers

    Which side effect is least likely to be experienced by patients taking COMT inhibitors?

    <p>Hypertension</p> Signup and view all the answers

    Why should tolcapone be used with caution compared to entacapone?

    <p>Higher risk of hepatotoxicity</p> Signup and view all the answers

    Which parameter is typically assessed to evaluate the effectiveness of istradefylline in Parkinson's patients?

    <p>Control of 'Off' episodes</p> Signup and view all the answers

    Which receptor is specifically targeted by istradefylline to exert its pharmacological effects?

    <p>Adenosine A2A</p> Signup and view all the answers

    What distinguishes amantadine from other treatments for Parkinson's disease?

    <p>It blocks NMDA receptors</p> Signup and view all the answers

    Which common side effect is most closely associated with amantadine therapy?

    <p>Livedo reticularis</p> Signup and view all the answers

    Antimuscarinics are primarily utilized to alleviate which symptom of Parkinson's disease?

    <p>Tremor</p> Signup and view all the answers

    What is the primary mechanism by which benztropine alleviates symptoms of Parkinson's disease?

    <p>Inhibits acetylcholine activity</p> Signup and view all the answers

    Which medication is most likely to alleviate motor symptoms when co-administered with levodopa?

    <p>A COMT inhibitor</p> Signup and view all the answers

    Which of the following is a common side effect encountered with antimuscarinic medications like benztropine?

    <p>Dry mouth</p> Signup and view all the answers

    In the management of essential tremor, which medication is considered first-line treatment?

    <p>Beta blockers</p> Signup and view all the answers

    Which of the following drugs is known to potentially exacerbate the symptoms of Parkinson's disease?

    <p>Metoclopramide</p> Signup and view all the answers

    Which beta blocker is specifically noted for its ability to cross the blood-brain barrier, enhancing its effectiveness for essential tremor?

    <p>Propranolol</p> Signup and view all the answers

    When initiating therapy for elderly patients with Parkinson's, what is a crucial initial strategy?

    <p>Use of dopamine agonists as first-line agents</p> Signup and view all the answers

    Which type of tremor is predominantly associated with essential tremor?

    <p>Postural tremor</p> Signup and view all the answers

    Which MAO-B inhibitor is known for potentially lessening the progression of Parkinson's disease?

    <p>Rasagiline</p> Signup and view all the answers

    In addition to inhibiting dopamine breakdown, what is another effect of MAO-B inhibitors in Parkinson's disease treatment?

    <p>Reduce oxidative stress</p> Signup and view all the answers

    Which of the following medications is most likely to exacerbate serotonergic side effects when combined with MAO-B inhibitors?

    <p>Fluoxetine</p> Signup and view all the answers

    What impact does the use of COMT inhibitors alongside levodopa therapy have on Parkinson's symptoms?

    <p>It prolongs the effectiveness of levodopa</p> Signup and view all the answers

    Among the following, which symptom shows the least responsiveness to dopaminergic therapy in patients with Parkinson's disease?

    <p>Cognitive impairment</p> Signup and view all the answers

    What is the unique side effect of amantadine treatment related to skin changes?

    <p>Livedo reticularis</p> Signup and view all the answers

    Which receptor subtype is primarily affected by adenosine A2A receptor antagonists in Parkinson's disease?

    <p>A2A</p> Signup and view all the answers

    Which of the following conditions was amantadine initially developed to treat?

    <p>Influenza</p> Signup and view all the answers

    Which symptom of Parkinson's disease do antimuscarinics help alleviate?

    <p>Tremor</p> Signup and view all the answers

    What is a potential adverse effect of dopamine agonists like pramipexole?

    <p>Impulse control disorders</p> Signup and view all the answers

    Which treatment modality is used for patients experiencing 'freezing' episodes of Parkinson's disease?

    <p>Apomorphine rescue treatment</p> Signup and view all the answers

    What is the primary target of antimuscarinic drugs in the context of Parkinson's disease treatment?

    <p>Muscarinic receptors</p> Signup and view all the answers

    Which dopamine agonist is known for its administration via a transdermal patch?

    <p>Rotigotine</p> Signup and view all the answers

    What is the main therapeutic purpose of COMT inhibitors in the context of treating Parkinson's disease?

    <p>Inhibit the breakdown of L-Dopa for increased efficacy</p> Signup and view all the answers

    Which adverse effect is frequently reported with tolcapone usage?

    <p>Elevated liver enzymes leading to hepatotoxicity</p> Signup and view all the answers

    What effect do COMT inhibitors typically have on the motor performance of Parkinson's patients?

    <p>Reduce the frequency and severity of motor function fluctuations</p> Signup and view all the answers

    In the treatment of Parkinson's disease, which medication is formulated with entacapone to improve patient compliance?

    <p>Stalevo®</p> Signup and view all the answers

    What clinical implication does reddish-brown urine have when a patient is on COMT inhibitors?

    <p>Generally considered a benign effect</p> Signup and view all the answers

    Which class of therapeutic agents are COMT inhibitors most effectively paired with for enhanced symptoms management in Parkinson's disease?

    <p>Levodopa/carbidopa regimens</p> Signup and view all the answers

    Identify the drug recognized as an adenosine A2A receptor antagonist that is utilized for treating Parkinson's disease.

    <p>Istradefylline</p> Signup and view all the answers

    What side effect is commonly associated with adenosine A2A receptor antagonists like Istradefylline?

    <p>Induction of dyskinesias</p> Signup and view all the answers

    Which adverse effect can amantadine cause in patients with Parkinson's disease?

    <p>Ankle edema</p> Signup and view all the answers

    What role does the NMDA receptor antagonist play in the management of Parkinson's disease?

    <p>Inhibits excitotoxicity</p> Signup and view all the answers

    Which therapeutic agent is primarily indicated for managing tremors associated with Parkinson's disease?

    <p>Benztropine</p> Signup and view all the answers

    Which lifestyle factor can exacerbate essential tremor symptoms?

    <p>Caffeine consumption</p> Signup and view all the answers

    What is typically used as a secondary treatment option for essential tremor when beta-blockers fail?

    <p>Topiramate</p> Signup and view all the answers

    Which medication for essential tremor is commonly associated with sedation?

    <p>Primidone</p> Signup and view all the answers

    Which type of tremor is most effectively managed with beta-blockers like propranolol?

    <p>Postural tremor</p> Signup and view all the answers

    Which tremor that occurs with purposeful movement is characteristic of essential tremor?

    <p>Kinetic tremor</p> Signup and view all the answers

    Study Notes

    Acetylcholine and Parkinson's Disease

    • Acetylcholine becomes overactive when dopamine levels drop in Parkinson's disease, contributing to symptoms.

    Basal Motor Pathway

    • Dopamine primarily inhibits cholinergic neurons in the basal ganglia, playing a crucial role in motor control.
    • In Parkinsonism, the inhibitory pathway becomes overactive due to dopamine deficiency.
    • The imbalance between dopamine and acetylcholine results in symptoms like tremor.

    Neurotransmitter Imbalance

    • Critical neurotransmitter imbalance in Parkinson's disease is between dopamine and acetylcholine.
    • GABA activity is affected; it becomes overactive due to excess acetylcholine from dopamine loss.
    • Dopamine deficiency increases inhibitory control of muscles through GABAergic signaling.

    Treatment Goals in Parkinsonism

    • Primary treatment goal is to increase dopaminergic neurotransmission for better symptom management.

    Drug Therapy Overview

    • Drug therapy aims to improve dopaminergic neurotransmission.
    • Bradykinesia is a common symptom of Parkinsonism.
    • Dopamine agonists constitute a major class of drugs used in treatment.

    Neuroanatomy of Parkinson's Disease

    • The substantia nigra is the neuroanatomical structure most affected in Parkinson's disease.
    • Resting tremor is a characteristic sign of Parkinsonism.
    • Antipsychotics can induce Parkinsonism symptoms as a side effect.

    Etiology and Pathogenesis

    • Proposed causes of Parkinson's disease include oxidative stress.
    • Mutations in the Parkin gene are associated with juvenile Parkinsonism.
    • Parkinson's disease typically manifests between ages 50-60.

    Motor Control Pathways

    • Basal ganglia are primarily involved in motor control affected by Parkinson's disease.
    • Dopamine is the deficient neurotransmitter leading to motor dysfunction.

    Carbidopa/Levodopa Treatment

    • Carbidopa inhibits peripheral conversion of levodopa to dopamine, enhancing efficacy.
    • Levodopa is most effective for relieving bradykinesia, a major symptom.
    • High-protein meals can delay the absorption of levodopa.

    Formulations of Carbidopa/Levodopa

    • Inbrija is used for on-demand relief of motor fluctuations.
    • Rytary is an extended-release capsule formulation for consistent symptom control.
    • Dyskinesia is the most common side effect of long-term Carbidopa/Levodopa therapy.

    Dopamine Agonists

    • Dopamine agonists, such as Pramipexole, are less associated with dyskinesia compared to levodopa.
    • They are effective for managing the on-off phenomena associated with Parkinson's disease.

    MAO-B Inhibitors

    • MAO-B inhibitors, like Rasagiline, inhibit dopamine breakdown and may provide neuroprotective effects.
    • Common side effect of MAO-B inhibitors is nausea.

    COMT Inhibitors

    • Tolcapone is a COMT inhibitor known for hepatotoxicity, while Entacapone is safer.
    • They reduce motor fluctuations by increasing dopamine availability in the brain.
    • A harmless side effect of COMT inhibitors includes red-brown discoloration of urine.

    Long-Term Side Effects of Treatment

    • Long-term Carbidopa/Levodopa use can lead to dyskinesia.
    • Adding a dopamine agonist can help reduce dyskinesia.
    • The use of Carbidopa/Levodopa is contraindicated in closed-angle glaucoma patients.

    Motor Complications

    • The on-off phenomenon involves sudden loss of levodopa effectiveness, unrelated to dosage timing.
    • Increasing the dose frequency can help reduce the "wearing-off" effect of levodopa.
    • A "drug holiday" can lead to severe immobility as a potential complication.

    Transdermal Dopamine Agonists

    • Rotigotine is a dopamine agonist that can be administered via a transdermal patch.
    • Common side effects of dopamine agonists include impulse control disorders, particularly with Pramipexole and Ropinirole.

    Dopamine Agonists (Pramipexole, Ropinirole)

    • Pramipexole primarily acts as an agonist for D2 and D3 receptors, enhancing dopamine signaling.
    • Ropinirole is more selective for D2 receptors compared to other dopamine agonists.
    • Common side effect of pramipexole and ropinirole includes sleep attacks, which can impact daily functioning.

    Dopamine Agonists (Rotigotine)

    • Rotigotine is administered via a transdermal patch, allowing for continuous drug delivery.
    • Diarrhea is not a side effect associated with rotigotine treatment.
    • A unique feature of rotigotine is its ability to provide continuous dopaminergic stimulation, beneficial for managing Parkinson's symptoms.

    MAO-B Inhibitors

    • MAO-B inhibitors, such as selegiline and rasagiline, specifically inhibit the enzyme monoamine oxidase-B, which breaks down dopamine.
    • Nausea is a commonly reported side effect of selegiline.
    • At high doses, selegiline may lose selectivity and inhibit monoamine oxidase-A, potentially leading to undesirable effects.

    Rasagiline and Safinamide

    • Rasagiline is recognized for its neuroprotective properties, making it a preferred choice among MAO-B inhibitors.
    • Safinamide acts as a reversible inhibitor of monoamine oxidase-B, aiding in dopamine metabolism.
    • Rasagiline is noted for higher potency compared to selegiline, enhancing therapeutic efficacy in Parkinson's disease management.

    MAO-B Inhibitors (Continued)

    • MAO-B inhibitors specifically target dopamine, increasing its availability in the brain.
    • Rasagiline is regarded as more potent and has neuroprotective effects, beneficial for long-term treatment.
    • Hallucinations can occur as a rare side effect in patients using MAO-B inhibitors, necessitating monitoring.

    COMT Inhibitors

    • COMT inhibitors help prevent the peripheral breakdown of levodopa, ensuring more levodopa reaches the brain.
    • Tolcapone is associated with hepatotoxicity, which restricts its clinical use compared to other COMT inhibitors.
    • A harmless side effect of COMT inhibitors, like Entacapone, is the occurrence of red-colored urine, which is due to changes in urine composition.

    Adenosine Antagonists

    • Istradefylline functions by antagonizing adenosine A2A receptors in the basal ganglia, contributing to the alleviation of Parkinson's symptoms.

    COMT Inhibitors

    • COMT inhibitors block the enzyme Catechol-O-methyltransferase to boost levodopa bioavailability.
    • Diarrhea is a common side effect associated with the use of COMT inhibitors.
    • Tolcapone carries a higher risk of hepatotoxicity, which leads to lesser usage compared to entacapone.

    Adenosine Antagonist

    • Istradefylline (Nourianz®) is primarily used to manage "off" episodes in Parkinson's disease.
    • It antagonizes the Adenosine A2A receptor to exert its therapeutic effects.
    • Dyskinesia is a notable side effect of istradefylline.

    Amantadine

    • Amantadine is particularly effective in treating dyskinesia in Parkinson's disease.
    • Its primary mechanism of action involves NMDA receptor blockade.
    • Livedo reticularis is a common side effect experienced with amantadine use.

    Antimuscarinics

    • Antimuscarinics are most effective in alleviating tremors associated with Parkinson's disease.
    • Memory impairment is a recognized side effect of antimuscarinics like benztropine.
    • Benztropine works by inhibiting acetylcholine activity, contributing to symptom relief in Parkinson's disease.

    Considerations

    • Initiating levodopa treatment in elderly patients often involves starting with dopamine agonists to minimize complications.
    • Metoclopramide can worsen Parkinson's symptoms due to its action of blocking dopamine receptors.
    • Adding a COMT inhibitor can effectively manage motor complications arising from long-term levodopa therapy.

    Essential Tremor

    • Beta blockers, particularly propranolol, are first-line treatments for essential tremor.
    • Essential tremor is characterized by intention tremors.
    • Lithium is known to potentially exacerbate essential tremor symptoms.

    Beta Blockers for Essential Tremor

    • Propranolol is the most commonly used beta blocker for treating essential tremor.
    • Propranolol is effective for essential tremor as it can cross the blood-brain barrier, providing better symptom control compared to other beta blockers like atenolol or metoprolol.

    COMT Inhibitors

    • COMT inhibitors primarily inhibit the breakdown of L-Dopa, enhancing its effectiveness in managing Parkinson's disease.
    • A notable side effect of tolcapone, a COMT inhibitor, is hepatotoxicity, which underscores the need for monitoring liver functions.
    • They help reduce fluctuations in motor function, but do not provide immediate symptom relief or eliminate dyskinesias.
    • Entacapone is combined with carbidopa/levodopa in the formulation Stalevo® to streamline Parkinson's drug regimens.
    • Reddish-brown urine can result from COMT inhibitors; this side effect is harmless and not indicative of toxicity.
    • COMT inhibitors are commonly used in conjunction with levodopa/carbidopa therapy.

    Adenosine Antagonists

    • Istradefylline is an adenosine A2A receptor antagonist indicated for Parkinson's treatment.
    • A common side effect associated with adenosine A2A receptor antagonists is dyskinesias.
    • Their mechanism of action involves blocking adenosine receptors, leading to improved motor function in Parkinson's patients.

    Amantadine

    • Amantadine is indicated as adjunctive therapy for dyskinesias in patients with Parkinson's disease.
    • A unique side effect of amantadine is livedo reticularis, which requires awareness by healthcare providers.
    • The drug was initially developed to treat influenza before being repurposed for Parkinson’s disease.

    Antimuscarinics

    • Antimuscarinics are particularly effective in targeting tremors in Parkinson's disease.
    • Memory impairment is a common side effect of antimuscarinics that can impact patient quality of life.
    • Benztropine, an antimuscarinic, is less effective than dopaminergic drugs specifically for improving bradykinesia.

    Dopamine Agonists

    • Apomorphine serves as a rescue treatment for "freezing" episodes in patients with Parkinson's disease.
    • Potential side effects of dopamine agonists, such as pramipexole, include impulse control disorders, which can significantly affect behavior.
    • Ropinirole primarily targets the D2 dopamine receptor subtype, influencing motor control in Parkinson's patients.

    MAO-B Inhibitors

    • Rasagiline is a commonly used MAO-B inhibitor for Parkinson's treatment.
    • The primary function of MAO-B inhibitors is to inhibit dopamine breakdown, thus prolonging dopaminergic action in the brain.
    • MAO-B inhibitors, like selegiline, are contraindicated in combination with SSRIs due to the risk of serotonin syndrome.

    Treatment Strategies

    • To manage the "wearing-off" effect of levodopa, adding a COMT inhibitor is a common strategy.
    • MAO-B inhibitors are often included to reduce motor complications associated with levodopa therapy.
    • Cognitive impairment is the symptom least likely to improve with dopaminergic therapy compared to bradykinesia, tremor, and rigidity.

    Amantadine and Antimuscarinics

    • Common side effect of amantadine in Parkinson's treatment: Ankle edema.
    • Amantadine's mechanism of action: NMDA receptor antagonist.
    • Antimuscarinic drug frequently used for Parkinson's tremor: Benztropine.

    Essential Tremor

    • Essential tremor is characterized by fine motor movement of fingers/hands during intentional movement.
    • First-line treatment for essential tremor: Beta-blockers.
    • Common aggravating factor for essential tremor: Caffeine.

    Additional Treatments for Essential Tremor

    • Alternative medication for essential tremor when beta-blockers are ineffective: Topiramate.
    • Medication used for essential tremor that may cause sedation as a side effect: Primidone.
    • Beta-blockers like propranolol are primarily used to treat postural tremor.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Related Documents

    Drugs for Movement Disorders Part 1 PDF
    Drugs for Movement Disorders Part 2 PDF
    Drugs for Movement Disorders Part 3-PDF
    Drugs for Movement Disorders Part 4 PDF
    Drugs for Movement Disorders Questions PDF

    Description

    This quiz explores the role of acetylcholine in the pathogenesis of Parkinson's disease, particularly its relationship with dopamine levels. Test your knowledge about neurotransmitters and their effects on the basal ganglia as it relates to motor control and disease states.

    More Like This

    Acetylcholine Receptors Quiz
    15 questions

    Acetylcholine Receptors Quiz

    NonViolentKyanite avatar
    NonViolentKyanite
    Acetylcholine (ACh) Neurotransmitter Process Overview Quiz
    6 questions

    Acetylcholine (ACh) Neurotransmitter Process Overview Quiz

    LustrousSerenity839 avatar
    LustrousSerenity839
    Mecanismo de Contracción Muscular y Calcio
    43 questions

    Mecanismo de Contracción Muscular y Calcio

    DedicatedRomanesque avatar
    DedicatedRomanesque
    Pharmacology of Acetylcholine and Receptors
    48 questions

    Pharmacology of Acetylcholine and Receptors

    EasierWilliamsite9554 avatar
    EasierWilliamsite9554
    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser