Parkinson's and Alzheimer's Disease Notes

anemones Metodopramide is Notuse Because of extrapyramidalsideeffect Neurologic: Parkinson’s disease (PD) bDopamine Treatment: A. Levodopa/Carbidopa:...

anemones Metodopramide is Notuse Because of extrapyramidalsideeffect Neurologic: Parkinson’s disease (PD) bDopamine Treatment: A. Levodopa/Carbidopa: EW # Dopa precursor of dopamine, dose depend on carbidopa # Carbidopa given with levodopa to prevent peripheral metabolism of levodopa # MOA of l-dopa: inc. DA level in brain !, leading to stimulate DA receptor ddd # Take it on empty (morning) B. Dopamine receptor agonist: Pramipexole, Ropinirole, Apomorphine, Rotigotine Ift C. Catechol-O-Methyltransferase (COMT) inhibitors: Tolcapone # Hepatotoxic D. Amantadine: Antiviral, Antiparkinsonian, DA agonist # cause Livedo reticularis “pigmentation” id # MOA of Amantadine: interfere with viral M2 protein function, blocking uncoating of the virus particles activityof Dopamine am E. Anticholinergic: Trihexyphenidyl image # cause mydriasis and CAG Coronary Angiogram (CAG) ya Parkinson patient with nausea ): if high dose of carbidopa decrease the dose 👆 Domperidone looks Medication for Parkinson cause dizziness: Apomorphine, Pramipexole, Ropinirole, Retigabine Psychosis in Parkinson patient: Quetiapine, Primavanserin G Sever mental disorder -------- Alzheimer disease (AD) back BlockofNMDA Raptor Treatment: A. Cholinesterase inhibitors: Donepezil, Rivastigmine, Glutamine o Mild - moderate: Donepezil, Rivastigmine, Glutamine o Advanced: ONLY Donepezil moderate or Sever HAN GI o Dementia + Alzheimer disease (AD): ONLY Rivastigmine DonepezilMemantine B. N-methyl-d-aspartate receptor antagonist: Memantine # MOA of memantine: antagonist effect atserotonin 5HT3 receptor, NMDA receptor & block nicotine acetylcholine receptor mim.si d BZDs used in Alzheimer (DACL): Diazepam, Alprazolam, Clonazepam, Lorazepam, Alzheimer patient with urinary urgency: Oxybutynin All stages: Donepezil In Urinary urgency: An immediate unstoppable urge to urinate, due to a sudden involuntary contraction of the muscular wall of the bladder. Moderate-sever: Memantine +/- Donepezil Herbal for Alzheimer disease*: Gingko biloba, Caprylidene cerepralBloodflow about.IT