Clotting Cascade Diagram PDF
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Uploaded by UnbiasedMossAgate2727
Edge Hill University
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Summary
This diagram describes the clotting cascade, a complex process that involves the intrinsic and extrinsic pathways. The intrinsic pathway is initiated by contact activation and the extrinsic pathway by tissue factor. Both pathways converge on the formation of thrombin which converts fibrinogen to fibrin to form a blood clot.
Full Transcript
# THE CLOTTING CASCADE ## INTRINSIC PATHWAY - Vessel Damage - Exposed Collagen - Contact activation - 12 - 12a - 11 - 11a - 9 - Absence = less common cause of hemophlia - 8 - 8a - 9a - 9 - Activated platelets - Cofactor - Phospholipid cofactor - Platelet factor (PF) - Actives plate...
# THE CLOTTING CASCADE ## INTRINSIC PATHWAY - Vessel Damage - Exposed Collagen - Contact activation - 12 - 12a - 11 - 11a - 9 - Absence = less common cause of hemophlia - 8 - 8a - 9a - 9 - Activated platelets - Cofactor - Phospholipid cofactor - Platelet factor (PF) - Actives platelets - 5 - 5a - Cofactor - Prothrombin (II) - 10 - 10a - Activated platelets - 2a - Thrombin (IIa) - Profound positive feedback effect ## EXTRINSIC PATHWAY - Subendothelial cells - Platelets - Tissue factor (III) - 1 - 7 - 7a - Produces many clotting factors - Liver >- Bile salts >- Vit K >- Required to produce prothrombin & clotting factor ## 2. - Fibrinogen - 13 - 13a - Cross linkages.
