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Clotting Pathway Instrinsic pathway damaged vessel/ exposed collagen Inactive factor XII Active factor XII Extrinsic pathway Tissue damage Factor III Ca2+ and factor VII Inactive factor XI Active factor XI Ca2+ Inactive factor IX Active factor IX Ca2+, PF3 and factor VIII Inactive factor X Active fa...

Clotting Pathway Instrinsic pathway damaged vessel/ exposed collagen Inactive factor XII Active factor XII Extrinsic pathway Tissue damage Factor III Ca2+ and factor VII Inactive factor XI Active factor XI Ca2+ Inactive factor IX Active factor IX Ca2+, PF3 and factor VIII Inactive factor X Active factor X Ca2+, PF3 and factor VIII Prothrombin Thrombin Fibrinogen Fibrin (loose meshwork) Fibrin (stabilised meshwork) Factor XIII Clot

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