Coagulation Pathway PDF
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Uploaded by ImmenseBliss6543
Badr University in Cairo
Abdullah wael mostafa ali
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Summary
This document explains the intrinsic and extrinsic pathways of the coagulation pathway. It discusses the factors involved and how they interact to cause blood clotting. The document includes the step-by-step details of each process.
Full Transcript
# Intrinsic Pathway - Activation occurs when blood is exposed to: - **In vivo:** Subendothelial collagen & catalyzed by kininogen and kallikrein. - **In vitro:** Electro-negatively charged - **XI** activates factor **XI** - **XIa** activates factor **IX** - **IXa** forms a complex with fact...
# Intrinsic Pathway - Activation occurs when blood is exposed to: - **In vivo:** Subendothelial collagen & catalyzed by kininogen and kallikrein. - **In vitro:** Electro-negatively charged - **XI** activates factor **XI** - **XIa** activates factor **IX** - **IXa** forms a complex with factor **VIIIa** - The complex of **IXa-VIIIa**, phospholipids of aggregated platelets, and calcium activates factor **X** - **X** converts prothrombin to thrombin # Extrinsic Pathway: - Tissue trauma, either vascular or extravascular will release thrombin which activates factor **VII** - **VIIa**, and **TPL** activate factors **IX** and **X** - **Xa**, in the presence of **PL**, calcium, and active factor **V**, converts prothrombin to thrombin. - Name: Abdullah wael mostafa ali - ID: 2400599
