CF55ACF8-5E79-4C55-894C-0C417EF3164C.pdf

Page 1 of 2 Study guide 1: Compare and Contrast Antiretroviral Agents Due: Monday, November 13th at 8 AM via Blackboard Part A. Instructions: For each medication listed in a given combination, identify its ARV class. The ARV class abbreviations to use in your response: NRTI, NNRTI, PI, and/or INSTI...

Page 1 of 2 Study guide 1: Compare and Contrast Antiretroviral Agents Due: Monday, November 13th at 8 AM via Blackboard Part A. Instructions: For each medication listed in a given combination, identify its ARV class. The ARV class abbreviations to use in your response: NRTI, NNRTI, PI, and/or INSTI. If there is -/r or -/c, identify it as a PK enhancer. For example, atazanavir + cobicistat will be identified as PI + PK enhancer. Example: Combination 1 Agent 1 Rilpivirine Agent 2 Emtricitabine Agent 3 TDF Example: Response: NNRTI NRTI NRTI Combination 2 Elvitegravir Cobicistat Emtricitabine TAF Your response: INSTI -/c PK enhancer NRTIs NRTI 3. Combination 3 Your response: Dolutegravir INSTI Lamivudine NRTI 4. Combination 4 Your response: Dolutegravir INSTI Abacavir NRTI Lamivudine NRTI 5. Combination 5 Your response: Efavirenz NNRTI Lamivudine NRTI TDF NRTI 1 2. Agent 4 Part B. Instructions: Highlight/circle the option(s) that apply to the given clue Clue Option A Option B Option C Option D 1 ARV agent target(s) Protease 2 Chelates with polyvalent cations Darunavir Reverse transcriptase Cobicistat Topoisomerase Integrase IV Dolutegravir Raltegravir Page 2 of 2 3 4 5 6 7 8 Avoid PPIs while on this/these ARV(s) Concerns for many DDIs due to CYP450 3A involvement Need a PK enhancer Available as an IM formulation Is considered 2nd generation Has activity against Hepatitis B virus Rilpivirine Efavirenz TDF TAF Ritonavir Cobicistat Rilpivirine Emtricitabine Darunavir TDF TAF Abacavir Elvitegravir Cabotegravir Emtricitabine Cabotegravir/rilpivirine Bictegravir Dolutegravir Rilpivirine Efavirenz Abacavir TAF TDF Emtricitabine Part C. Instructions: Highlight/circle one or all drug(s) in which the listed adverse effect is likely to occur. Clue Option A Option B Option C Option D 1 Weight gain Emtricitabine Bictegravir TAF Dolutegravir 2 Exacerbation of psychiatric illness Nephrotoxicity Rilpivirine Lamivudine Efavirenz TAF TAF TDF Abacavir Ritonavir Elevated serum creatinine (without a decline in GFR) rilpivirine dolutegravir cobicistat bictegravir 3 4