HIV Objectives PDF
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Augsburg University
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Summary
This document provides an overview of HIV, including six classes of antiretroviral agents and their mechanisms of action, and the pathophysiology associated with the disease. It also discusses the role of the CD4 count in managing HIV.
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1. **Six Classes of HIV Antiretroviral Agents and Mechanism of Action**: - **NRTIs** (Nucleoside Reverse Transcriptase Inhibitors): Prevent viral RNA from being transcribed into DNA. - **NNRTIs** (Non-Nucleoside Reverse Transcriptase Inhibitors): Also prevent trans...
1. **Six Classes of HIV Antiretroviral Agents and Mechanism of Action**: - **NRTIs** (Nucleoside Reverse Transcriptase Inhibitors): Prevent viral RNA from being transcribed into DNA. - **NNRTIs** (Non-Nucleoside Reverse Transcriptase Inhibitors): Also prevent transcription of viral RNA into DNA. - **PIs** (Protease Inhibitors): Prevent the release of mature virus particles from infected cells. - **Integrase Inhibitors**: Inhibit the integration of viral DNA into host DNA. - **Fusion Inhibitors**: Block viral entry into cells. - **CCR5 Inhibitors**: Prevent viral entry by blocking the CCR5 receptor. 2. **Pathophysiology of HIV and Importance of CD4 Count**: - HIV targets cells expressing CD4, such as T-helper cells, leading to progressive immunodeficiency. The CD4 count is a critical marker: a low count (\
