Pharmacology Notes PDF
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Uploaded by SophisticatedTulsa2777
Nicolaus Copernicus University in Toruń
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Summary
These notes provide a table outlining various drug agents, their mechanisms of action (MOA), side effects, and uses. Topics including direct-acting and mixed-acting agonists, as well as selective agonists are discussed. The document is likely a set of lecture notes or study materials for a pharmacology course.
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## Agonists ### Group | Drug Agent | MOA | (SE) Side Effects | Indications | Contra indications ------- | -------- | -------- | -------- | -------- | -------- Direct-Acting Agonists (Non-selective) | Epinephrine (3) | - α1: Vasoconstriction, ↑ BP <br>- β1: TAV conduction, ↑ force; THR<br> - β2: Bro...
## Agonists ### Group | Drug Agent | MOA | (SE) Side Effects | Indications | Contra indications ------- | -------- | -------- | -------- | -------- | -------- Direct-Acting Agonists (Non-selective) | Epinephrine (3) | - α1: Vasoconstriction, ↑ BP <br>- β1: TAV conduction, ↑ force; THR<br> - β2: Bronchodilation, lungs | - Hypertension <br>- Arrhythmias <br> - MI <br>- Anxiety <br> - Head aches | - Anaphylaxis | - Glaucoma <br>- Halothane anesthesia | Norepinephrine (2) | - α1: vasoconstriction, ↑ BP <br>- β1: TAV conduction, ↑ force; THR | - Arrythmias <br>- Hypetersion <br>- Angina Pecton's <br>- MI <br>- IR8F | - Cardiac Arrest <br>- Hypotensive shock | - Hypertension <br>- Blood clot <br>- Pheochromocytoma | Dopamine (3) | - D1 & α1: Vasoconstriction, TBP <br>- β1: TAV conduction, ↑ force; THR | - Arrhythmias <br>- Hypotension <br>- Angina <br>- Nausea | - Acute HF <br>- Hypotensive shock | - Acidosis <br>- Ventricular Arrhythmias ### Mixed-Acting Agonists | Drug Agent | MOA | (SE) Side Effects | Indications | Contra indications ------- | -------- | -------- | -------- | -------- | -------- | Ephedrine | - Activates Adrenergic receptors → release of NE <br>- NE causes: <br> -Vasoconstriction (α1) <br> -Bronchodilation (β2) <br>- Rarely used | - | - Decongestant | - | Pseudoephedrine | - α Adrenergic receptors → release of NE <br>- NE causes: <br> -Vasoconstriction (α1) <br> -Bronchodilation (β2) <br> -↓ Nasal inflammation <br> -↓ Nasal mucus | - | - Decongestant | - ### Selective Agonists | Drug Agent | MOA | (SE) Side Effects | Indications | Contra indications ------- | -------- | -------- | -------- | -------- | -------- α1 | Phenylephrine | - α1 → vasoconstriction → ↑ BP <br> - α1 → mydriasis | HABAV <br>- Hypertension<br> - Arrhythmias <br>- Bradycardia <br>- Anxiety <br> - Vomiting <br> - Chest pain | DMN <br>- Decongestion (pupil dilation) <br>- Mydriasis <br> - Newrogenic hypotension | OA <br>- Acidosis <br>- Overactive thyroid α2 | Clonidine "action PNS & CNS" | - Taken orally → activate α2 PCR →↓ NE release → Vasodilation →↓ HR →↓CO →↓ BP | - Hypotension <br>- Arrythmias <br>- Bradycardia <br>- Insomnia <br>- Head aches <br>- RBC break down <br> - Liver problems <br> - Hypersensitivity <br>- Insomnia | - Hypertension <br>- ADHD <br>- Spasticity <br>- Glaucoma <br>- Drug withdrawal <br>- Hypotension (Used during pregnancy) | - Pregnancy <br>- Heart attack <br>- Dry eyes <br>- Depression <br>- Anemia <br>- Liver impairments <br> - Mono Amine Oxidase Inhibitors (MAOI) <br> - β β | | Methyldopa "primarily act on CNS" | | | | | |
