IL Interleukins PDF

\#\#\# \*\*IL-1 (Interleukin-1)\*\* \- \*\*Role:\*\* IL-1 is a pro-inflammatory cytokine that plays a major role in the body\'s immune response to infections and injury. \- \*\*Functions:\*\* It promotes inflammation, fever, and the activation of immune cells like T cells and macrophages. \- \*\*...

\#\#\# \*\*IL-1 (Interleukin-1)\*\* \- \*\*Role:\*\* IL-1 is a pro-inflammatory cytokine that plays a major role in the body\'s immune response to infections and injury. \- \*\*Functions:\*\* It promotes inflammation, fever, and the activation of immune cells like T cells and macrophages. \- \*\*Key subtypes:\*\* IL-1α and IL-1β. \#\#\# \*\*IL-2 (Interleukin-2)\*\* \- \*\*Role:\*\* IL-2 is critical for the growth, proliferation, and survival of T cells. \- \*\*Functions:\*\* It stimulates the expansion of T cells after they have been activated. It also promotes the function of regulatory T cells (which help control immune responses). \#\#\# \*\*IL-3 (Interleukin-3)\*\* \- \*\*Role:\*\* IL-3 supports the growth and differentiation of blood cells. \- \*\*Functions:\*\* It stimulates the production of various blood cell types, including red blood cells, white blood cells, and platelets, in the bone marrow. \#\#\# \*\*IL-4 (Interleukin-4)\*\* \- \*\*Role:\*\* IL-4 is primarily involved in promoting the differentiation of T helper cells. \- \*\*Functions:\*\* It stimulates the production of antibodies by B cells (especially IgE), helps the development of Th2 cells, and is important in allergic responses. \#\#\# \*\*IL-5 (Interleukin-5)\*\* \- \*\*Role:\*\* IL-5 is important for the activation and growth of eosinophils (a type of white blood cell). \- \*\*Functions:\*\* It plays a key role in defense against parasitic infections and in the pathogenesis of allergic diseases like asthma. \#\#\# \*\*IL-6 (Interleukin-6)\*\* \- \*\*Role:\*\* IL-6 is a multifunctional cytokine that is involved in inflammation and immune response. \- \*\*Functions:\*\* It helps in fever production, stimulates the production of acute-phase proteins, and is involved in the differentiation of B cells into antibody-producing cells. It also helps activate T cells. \#\#\# \*\*IL-7 (Interleukin-7)\*\* \- \*\*Role:\*\* IL-7 is crucial for the development and survival of T cells. \- \*\*Functions:\*\* It promotes the survival of naive T cells and the development of early-stage T cells in the thymus. \#\#\# \*\*IL-8 (Interleukin-8)\*\* \- \*\*Role:\*\* IL-8 is primarily a chemokine (a signaling protein that attracts immune cells to sites of infection or inflammation). \- \*\*Functions:\*\* It attracts neutrophils (a type of white blood cell) to the site of infection or injury and is involved in inflammation. \#\#\# \*\*IL-10 (Interleukin-10)\*\* \- \*\*Role:\*\* IL-10 is an anti-inflammatory cytokine. \- \*\*Functions:\*\* It suppresses the immune response to prevent excessive inflammation, promotes the differentiation of regulatory T cells, and helps control autoimmune diseases. \#\#\# \*\*IL-12 (Interleukin-12)\*\* \- \*\*Role:\*\* IL-12 is important for the activation of Th1 cells. \- \*\*Functions:\*\* It stimulates the production of interferon-gamma (IFN-γ) by T cells and natural killer (NK) cells, helping to promote the immune response against infections, especially those caused by intracellular pathogens like viruses and certain bacteria. \#\#\# \*\*IL-13 (Interleukin-13)\*\* \- \*\*Role:\*\* IL-13 is similar to IL-4 and plays a role in allergic responses and inflammation. \- \*\*Functions:\*\* It regulates the production of mucus and promotes the differentiation of Th2 cells, aiding in allergic reactions such as asthma. \#\#\# \*\*IL-17 (Interleukin-17)\*\* \- \*\*Role:\*\* IL-17 is produced by Th17 cells and is involved in the body\'s defense against fungal and bacterial infections. \- \*\*Functions:\*\* It promotes inflammation, activates immune cells, and induces the production of other inflammatory cytokines, helping to defend against infections at mucosal surfaces. \#\#\# \*\*IL-21 (Interleukin-21)\*\* \- \*\*Role:\*\* IL-21 is produced by Th17 and T follicular helper cells. \- \*\*Functions:\*\* It plays a role in the differentiation of B cells, enhances the immune response to infections, and is involved in autoimmune diseases. \#\#\# \*\*IL-22 (Interleukin-22)\*\* \- \*\*Role:\*\* IL-22 is produced by Th17 cells and other immune cells. \- \*\*Functions:\*\* It helps protect the barrier functions of tissues, particularly at mucosal surfaces like the skin and intestines, by promoting tissue repair and inflammation during infection. \#\#\# \*\*IL-23 (Interleukin-23)\*\* \- \*\*Role:\*\* IL-23 is important for the development of Th17 cells. \- \*\*Functions:\*\* It helps sustain Th17 cell responses and plays a critical role in inflammatory diseases and autoimmune conditions, such as psoriasis and Crohn\'s disease. \#\#\# \*\*IL-33 (Interleukin-33)\*\* \- \*\*Role:\*\* IL-33 is an alarmin that is released from damaged tissues. \- \*\*Functions:\*\* It activates immune cells, including Th2 cells, mast cells, and eosinophils, and is involved in allergic diseases and asthma. \#\#\# \*\*IL-35 (Interleukin-35)\*\* \- \*\*Role:\*\* IL-35 is produced by regulatory T cells. \- \*\*Functions:\*\* It has anti-inflammatory properties and helps to suppress immune responses to prevent autoimmune diseases. \#\#\# \*\*IL-36 (Interleukin-36)\*\* \- \*\*Role:\*\* IL-36 is involved in the regulation of immune responses, particularly in skin-related immune activities. \- \*\*Functions:\*\* It promotes inflammation and can be involved in skin conditions like psoriasis. \#\#\# \*\*IL-37 (Interleukin-37)\*\* \- \*\*Role:\*\* IL-37 is a suppressor of inflammation. \- \*\*Functions:\*\* It helps regulate the immune system by reducing inflammation and inhibiting the production of pro-inflammatory cytokines. \-\--