Hemoglobin Structure and Function PDF
Document Details
Uploaded by SuperiorAntigorite4686
LMU College of Dental Medicine
Tags
Summary
This document describes the structure and function of hemoglobin, including its role in oxygen transport and the steps involved in heme synthesis. It also touches on porphyrias and their treatments.
Full Transcript
Structure and Function of Hemoglobin Hemoglobin (Hb) Chromosome 16 codes for the alpha chains • Globular hemeprotein in RBCs Chromosome 11 codes for the beta chains • Transports oxygen/CO2 • 2 parts: o Globin: Made of 4 polypeptide chains: 2 alpha (on chromosome 16) and 2 beta (on chromosome 11) o H...
Structure and Function of Hemoglobin Hemoglobin (Hb) Chromosome 16 codes for the alpha chains • Globular hemeprotein in RBCs Chromosome 11 codes for the beta chains • Transports oxygen/CO2 • 2 parts: o Globin: Made of 4 polypeptide chains: 2 alpha (on chromosome 16) and 2 beta (on chromosome 11) o Heme: A complex of iron and protoporphyrin IX found in Mb and Hb § Functions as: — Electron carrier: Oxidation/reduction rxns — Part of an enzyme’s active site: catalase for hydrogen peroxide breakdown — Reversible oxygen binder: Oxygen transport within cardiac/skeletal muscle Steps of Heme formation (know highlights on scheme) Porphyrias • â heme synthesis • Genetically inherited (most autosomal dominant, but congenital is recessive) Tx of Porphyrias • Hemin (Fe3+) injection: â ALA synthase activity • Avoid Sunlight • Ingest Beta Carotene: is a Free radical scavenger
