Non-Clinical Practice Questions - Notes PDF (2024)

2024-12-02 7) ORGANIC CHEMISTRY NON-CLINICAL REVIEW...

2024-12-02 7) ORGANIC CHEMISTRY NON-CLINICAL REVIEW 36 AND PRACTICE PEBC QUESTIONS Preparatory Course 09 EE Preparatory Course :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 1 a nk QUESTION 1 iya Pr Competitive inhibition reaction are characterized by A. Decrease in both Vmax and EC50. to B. Decrease in Km while no change in EC50 ed C. No change in Vmax and increase in EC50 D. Increase in EC50and decrease in Vmax ns ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 2 1  2024-12-02 QUESTION 2 Which of the following agents can be given to oppose the adverse effects that methotrexate? A. Erythropoietin B. Leucovorin 7) C. Acetylcysteine D. Vitamin K 36 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 3 a nk QUESTION 3 iya Pr Which of the following agents is appropriate to treat the acute alcohol withdrawal symptoms (nausea, tremors, hallucination)? to A. Naltrexone B. Diazepam ed C. Fomepizole D. Ethanol ns ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 4 2  2024-12-02 QUESTION 4 Which of the following agents acts as α2-receptor agonist in the spinal cord to reduce muscle spasm? A. Tizanidine B. Midazolam 7) C. Baclofen 36 D. Dantrolene 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 5 a nk QUESTION 5 iya Pr A patient is the following regimen: Day 1: 10 mg prednisolone to Day 2: 8 mg prednisolone Day 3: 6 mg prednisolone ed Day 4: 4 mg prednisolone Day 5: 2 mg prednisolone ns Day 6: 1 mg prednisolone How many whole tablet strength are required to give the patient considering that the available ce prednisolone strength are 4 mg and 1 mg tablets that CANNOT be split? A. Six 4 mg tablets and seven 1 mg tablets Li B. Five 4 mg tablets and four 1 mg tablets C. Eight 4 mg tablets and four 1 mg tablets D. Six 4 mg tablet and five 1 mg tablets Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 6 3  2024-12-02 QUESTION 6 The posterior pituitary stores and releases: A. ADH and Oxytocin B. Prolactin and ADH 7) C. Prolactin and oxytocin 36 D. ADH and Calcitonin 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 7 a nk QUESTION 7 iya Pr Which one of the followings is an early intermediate in cholesterol synthesis? to A. Mevalonate B. Acetyl CoA ed C. Squalene D. Lanosterol ns ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 8 4  2024-12-02 QUESTION 8 How many ml of a 6% w/v solution would you take in order to deliver a single dose of 10 mg? A. 4.0 mL B. 0.16 mL 7) C. 0.2 mL 36 D. 0.5 mL 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 9 a nk QUESTION 9 iya Pr How much hydrocortisone powder should be added to 200 g of the 1% w/w hydrocortisone to ointment to produce a 4% w/w hydrocortisone ointment? A. 0.90 g ed B. 6.25 g C. 9.58 g ns D. 21.0 g ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 10 5  2024-12-02 QUESTION 10 Transcription is the step that converts: A. cDNA to DNA B. RNA to DNA 7) C. DNA to RNA 36 D. RNA to protein 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 11 a nk QUESTION 11 iya Pr Blindness may be due to deficiency in to A. Vitamin A B. Vitamin K ed C. Vitamin B D. Vitamin C ns ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 12 6  2024-12-02 QUESTION 12 The plasma concentration of the following medications decrease as a result of Cigarette smoking (induces CYP1A2) except A. Clozapine B. Olanzapine 7) C. Methadone 36 D. Digoxin 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 13 a nk QUESTION 13 iya Pr Deficiency of Niacin causes A. Rickets to B. Pellagra C. Scurvy ed D. Pernicious anemia ns ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 14 7  2024-12-02 QUESTION 14 Estimate the volume of distribution of phenytoin for a patient after IV administrating of 200 mg phenytoin with peak plasma concentration of 4 mg/L A. 25 L 7) B. 50 L C. 75 L 36 D. 100 L 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 15 a nk QUESTION 15 iya Pr Which of the following intravenous loading dose is suitable for a 66-year-old female patient (weigh= 143 Ib) and volume of distribution = 0.25 L/kg to achieve an antibiotic concentration to between 7 and 9 mg/L? A. 75 mg ed B. 125 mg C. 190 mg ns D. 260 mg ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 16 8  2024-12-02 QUESTION 16 Zidovudine-induced neutropenia can be managed by: A. Erythropoietin B. Saquinavir 7) C. Filgrastim 36 D. Iron dextran 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 17 a nk QUESTION 17 iya Pr Abciximab inhibits: to A. Binding of fibrinogen to platelet surface B. Binding of ADP to its platelet receptor ed C. Activation of factor X D. Synthesis of factor II ns ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 18 9  2024-12-02 QUESTION 18 The most important store for iron is A. Transferrin B. Myoglobin 7) C. Ferritin D. Hemoglobin 36 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 19 a nk QUESTION 19 iya Pr Which of the following agents is appropriate for 30-year-old woman who suffer from to menorrhagia, low red blood cell count, low mean corpuscular volume, low hemoglobin level and low serum ferritin relative to normal lab values? ed A. Folic acid B. Erythropoietin ns C. Filgrastim D. Ferrous sulfate ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 20 10  2024-12-02 QUESTION 20 Management of transfusional iron overload can be done using A. Oprelevekin B. Filgrastim 7) C. Deferoxamine 36 D. Erythropoietin 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 21 a nk QUESTION 21 iya Pr Which of the following drugs helps in neutrophiles recovery in patients treated for cancer? to A. Filgrastim B. Oprelvekin ed C. Erythropeitin D. Darbepoetin ns ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 22 11  2024-12-02 QUESTION 22 FOBT, also known as guaiac smear test, is used to screen for A. Prostate cancer B. Colorectal cancer 7) C. Cervical cancer 36 D. Benign prostate hyperplasia 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 23 a nk QUESTION 23 iya Pr All of the following agents can increase lithium toxicity except to A. NSAIDs B. Thiazide diuretics ed C. Increase Na intake D. ACE inhibitors ns ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 24 12  2024-12-02 QUESTION 24 The cardiac glycoside digoxin bind to A. Sodium/calcium-ATPase B. Sodium/potassium-ATPase 7) C. Ca2+ channel D. K+ channel 36 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 25 a nk QUESTION 25 iya Pr All of the following medications when administrated with Digoxin can cause toxicity, Except? A. Amiodarone to B. Verapamil ed C. Quinidine D. Colestipol ns ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 26 13  2024-12-02 QUESTION 26 The hormones responsible for gluconeogenesis (transforms non-carbohydrate substrates such as lactate, amino acids, and glycerol) into glucose in the liver is: A. Glucagon B. Insulin 7) C. Thyroxine 36 D. Epinephrine 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 27 a nk QUESTION 27 iya Pr A 65-year-old man suffering from cancer started a chemotherapy cycle. Following that, a treatment with Oprelvekin was started to activate the receptors on to A. Platelets B. Megakaryocytes ed C. Neutrophils D. Lymphoblasts ns ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 28 14  2024-12-02 QUESTION 28 Which of the following agents increase lamotrigine plasma levels by inhibiting lamotrigine's glucuronidation? A. Phenytoin 7) B. Valproic acid 36 C. Gabapentin D. Levetiracetam 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 29 a nk QUESTION 29 iya Pr Which of the following agents is not hepatotoxic? to A. Dronaderone B. Valproic acid ed C. Lithium D. Terbinafine ns ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 30 15  2024-12-02 QUESTION 30 For IV two compartment model, which of the following statements is not true? A. The log plasma concentration-time graph has two phases B. Equilibrium between central compartment and peripheral compartment is rapid 7) C. Absence of the absorption phase D. Two exponential terms are included in the plasma Concentration equation 36 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 31 a nk QUESTION 31 iya Pr Calculate gentamycin plasma concentration at 4 h following the intravenous bolus dose of 5 to mg/ kg knowing that Gentamycin elimination half life is 3 hours and apparent volume of distribution equals to 0.20 L /Kg. ed A. 5.8 mcg/ L B. 3.2 mg/ L ns C. 9.9 mg/L D. 6.9 mg/h ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 32 16  2024-12-02 QUESTION 32 Determine the administered dose of an antibiotic with half life a 4 h and the apparent volume of distribution of 2.25 L /kg. The plasma concentration of this antibiotic was 1 mcg/ mL after 6 h from intravenous bolus administration. A. 4.9 mg/ kg B. 6.4 mg/ kg C. 7.9 mg/kg 7) D. 8.0 mg/kg 36 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 33 a nk QUESTION 33 iya Determine the absolute bioavailability of aminophylline knowing that the administration of 42.5 Pr mg of an intravenous solution of aminophylline has AUC of 35.84 mg. h/ mL. Oral administration of 150 mg tablet showed AUC of 126.4 mg. h/ mL. A. 0.80 to B. 1.00 C. 1.20 ed D. 1.80 ns ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 34 17  2024-12-02 QUESTION 34 Which of the following bacteria most likely caused severe sore throat for a boy who was prescribed Penicillin G? A. Streptococcus pyogenes 7) B. Enterococcus faecalis C. Haemophilus influenza 36 D. Staphylococcus aureus 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 35 a nk QUESTION 35 iya Pr Gram-negative rod shaped bacteria were identified in the pus secreted from the painful ulcer on to the penis of a man after unprotected intercourse. Which of the following antibiotics would be the most appropriate? A. Vancomycin ed C. Penicillin G D. Doxycycline ns E. Metronidazole ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 36 18  2024-12-02 QUESTION 36 Which one of the following gram-positive bacteria is cause of postpartum breast infection (mastitis)? A. Listeria monocytogenes 7) B. Escherichia coli C. Enterococcus faecalis 36 D. Staphylococcus aureus 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 37 a nk QUESTION 37 iya Pr Which of the following drugs combinations would be suitable for the treatment of UTI to caused by gram-positive Enterococcus faecalis? A. Moxifloxacin and cefoxetin ed B. Azotreonam and cefepime C. Penicillin G and erythromycin ns D. Ampicillin and gentamycin ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 38 19  2024-12-02 QUESTION 38 Which one is most likely offending pathogen and treatment of Gram-negative coccobacilli present in the discharge from the crusted lesion on a girl bitten by her dog couple of days back? A. Pasteurella multocida: Amoxicillin/​clavulanate 7) B. Staphylococcus epidermidis: Cloxacillin C. Clostridium difficile: metronidazole 36 D. Escherichia coli: vancomycin 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 39 a nk QUESTION 39 iya Pr Which one of the following drug is the suitable to treat the red, painless ulcer on a man’s penis. to Spiral organisms were identified by microscopical investigation in the ulcer? A. Linzeolid ed B. Moxifloxacin C. Penicillin G ns D. Gentamycin ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 40 20  2024-12-02 QUESTION 40 Which of the following drugs is included the treatment regimen of a 53-year-old woman with breast cancer is HER-2 (human epidermal growth factor receptor 2) positive? A. Raloxifene 7) B. Fluvestrant 36 C. Trastuzumab D. Flutamide 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 41 a nk QUESTION 41 iya Pr A Which of the following is the mechanism of action of doxorubicin? to A. It blocks the synthesis of both RNA and DNA. B. It prevents assembly of tubulin into microtubules. ed C. It alkylates DNA bases. D. It intercalates between DNA strands and inhibits topoisomerase II. ns ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 42 21  2024-12-02 QUESTION 42 Which of the following side effects would be expected to occur during treatment of a woman with leuprolide? A. Galactorrhea 7) B. Deep vein thrombosis 36 C. Menorrhagia D. Hot flashes 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 43 a nk QUESTION 43 iya Pr The mechanism of action of goserelin in treatment of prostate cancer is to A. Blockade of testosterone receptors in prostate B. Blockade of gonadotropin receptors in anterior pituitary ed C. Inhibition of aromatase enzyme D. Inhibition of FSH and LH release ns ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 44 22  2024-12-02 QUESTION 44 The laboratory test that is used to determine whether anemia is microcytic, normocytic, or macrocytic is known as A. Mean Corpuscular Volume 7) B. Mean Corpuscular Hemoglobin 36 C. Mean Corpuscular Hemoglobin Concentration D. Red Cell Distribution Width 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 45 a nk QUESTION 45 iya Pr Iron deficiency anemia is characterized by to A. Increased TIBC, Decreased Serum Ferritin B. Increased Iron, Increased TIBC ed C. Decreased TIBC, Increased Serum Ferritin D. Decreased Iron, Normal TIBC ns ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 46 23  2024-12-02 QUESTION 46 A cancer patient complained from shortness of breath after lying down, tachycardia, pulmonary and ankle edema, generalized fatigue after starting his chemotherapy regimen. Which agent might cause these symptoms? A. Ifosfamide 7) B. Doxorubicin C. Vinblastine 36 D. Rituximab 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 47 a nk QUESTION 47 iya Pr Which of the is the mechanism of action of Etoposide? A. RNA polymerase enzyme inhibitor to B. Prevention repair of broken strands of DNA C. Microtubule disassembly inhibitor ed D. DNA gyrase enzyme Inhibitor ns ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 48 24  2024-12-02 QUESTION 48 Which of the following agents is the antidote for dabigatran? A. Idarucizumab B. N acetyl cysteine C. Protamine Suphate 7) D. Vitamin K 36 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 49 a nk QUESTION 49 iya Pr Carbamazepine maintenance dose is usually higher than the starting dose due to A. decrease in hepatic extraction to B. Cytochrome enzyme auto induction C. Tachyphylaxis ed D. Renal clearance increased ns ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 50 25  2024-12-02 QUESTION 50 All of the following enzymes are present in Phase I metabolic reaction EXCEPT A. Glucuronyltransferase B. Epoxide hydrolase 7) C. Flavin monooxygenases 36 D. Cytochrome P450 oxidases 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 51 a nk QUESTION 51 iya Pr All of the followings represent heme-containing proteins EXCEPT to A. Cytochrome P450 monooxygenases B. Myoglobin ed C. Hemoglobin D. Angotensin converting enzymes ns ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 52 26  2024-12-02 QUESTION 52 The conversion of Acetone into isopropentol is an example of 7) 36 09 A. Keto-enol tautomerism B. Enamine-imine tautomerism :1 C. Lactam-lactim tautomerism D. Resonance (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 53 a nk QUESTION 53 iya Pr All of the following are true regarding Octreotide except : to A. It decrease growth hormone secretion B. It is used to manage acromegaly ed C. It is orally administrated D. It is used in severe diarrhea ns ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 54 27  2024-12-02 QUESTION 54 The appropriate antidote for a young girl who is in semiconscious state and suffering from hypotension and bradycardia after taking her father’s bisoprolol tablets is A. Glucagon B. Naloxone 7) C. Physostigmine D. Epinephrine 36 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 55 a nk QUESTION 55 iya The most suitable treatment for a farmer who was exposed to parathion while cleaning his Pr pesticide storage cabinet is: A. Atropine and pralidoxime to B. Diazepam C. Hydroxycobaltamine ed D. Hyperbaric oxygen ns ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 56 28  2024-12-02 QUESTION 56 Which one of the following drugs if taken in overdoses can cause confusion, hypotension, seizures, and cardiac arrhythmia? A. Acetaminophen B. Clonazepam 7) C. Sufentanil 36 D. Amitriptyline 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 57 a nk QUESTION 57 iya Pr Nervousness, weight loss, difficulty sleeping, and blood pressure may be due to A. Decreased catecholamines to B. Decreased TSH C. Increased ACTH ed D. Increased calcitonin ns ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 58 29  2024-12-02 QUESTION 58 Phase II metabolic reaction includes: A. Ketones reduction B. Glutathione addition C. Dealkylation 7) D. Ester hydrolysis 36 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 59 a nk QUESTION 59 iya Pr During cell cycle, DNA replicates during A. Go phase to B. G1 phase C. G2 phase ed D. S phase ns ce Li Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 60 30  2024-12-02 QUESTION 60 Chancroids is a sexual transmitted disease caused by: A. Haemophilus ducreyi B. Chlamydia trachomatis 7) C. Treponema pallidum 36 D. Herpes Simplex 09 :1 (ID e or M Copyright © 2022 PharmAchieve Corporation Ltd. Private and Confidential. 61 a nk iya Pr to ed ns ce Li 31