photo.jpg

## Cardiology ### Drug Induced CMP * **Anthracyclines** * Doxorubicin * Daunorubicin * Mitoxantrone * **Trastuzumab** (In carcinoma breast). * **Cyclophosphamide** * **VEGF** inhibitors. * **Proteasome** inhibitors. **Note:** * **Chemotherapeutic** uses of anthracyclines: * **N...

## Cardiology ### Drug Induced CMP * **Anthracyclines** * Doxorubicin * Daunorubicin * Mitoxantrone * **Trastuzumab** (In carcinoma breast). * **Cyclophosphamide** * **VEGF** inhibitors. * **Proteasome** inhibitors. **Note:** * **Chemotherapeutic** uses of anthracyclines: * **Non-Hodgkins** lymphoma: Hydroxydaunorubicin in R-CHOP regime. * **Hodgkins** lymphoma: Adriamycin (Doxorubicin) in ABVD regime. * **AML**: 7+3 regime. ### Alcohol Induced * **Pathophysiology:** ACE polymorphism → Formation of acetaldehyde → Cardiomyopathy. * **Additional Risk** (Associated with alcohol) * **Atrial fibrillation** (Holiday Heart syndrome). * **Stroke** * **ACS** * **Aggravating factors:** Deficiencies of * **Thiamine** * **Magnesium** * **Selenium** * **Treatment:** Avoid alcohol (Reversible: EF improves after 3-6 months). ### Myocarditis * **Inflammatory Dilated CMP** * Focal * Diffuse * **Onset:** Acute → Chronic (3 months). * **Etiology:** Post viral * **HHV-6:** m/c cause. * **Trypanosoma cruzi** (Chaga's disease) * **Pathophysiology:** * Systemic infection - Severe cytokine release ↓ LV function. Medicine. v1.0. Marrow 8.0. 2024