Metabolism of Free Fatty Acids Lecture Summary

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18 Questions

Which molecule transports free fatty acids to tissues like muscle for energy production?

Serum albumin

Why can't plasma free fatty acids be used for fuel by red blood cells?

Red blood cells lack mitochondria

In which organelle are fatty acids oxidized for energy production?

Mitochondria

What is the fate of over 50% of fatty acids released from adipose tissue?

Reesterified to glycerol 3-phosphate

Under what conditions does beta-oxidation of fatty acids increase?

During prolonged fasting

Which step must occur for beta-oxidation of fatty acids to take place?

Activation of fatty acids to acyl CoA derivatives

What is the primary form in which fatty acids are stored in white adipose tissue?

Triacylglycerols (TAGs)

What enzyme initiates the process of lipolysis by generating diacylglycerol?

Adipose Triglyceride Lipase (ATGL)

What is the preferred substrate for Hormone Sensitive Lipase (HSL) in the process of lipolysis?

Diacylglycerol

Which hormones activate the process of lipolysis?

Catecholamines

What are the end products of lipolysis?

Glycerol and Free fatty acids

How many kilocalories per gram are yielded from the complete oxidation of fatty acids, compared to proteins or carbohydrates?

$9$ kcal/g fat

What is the first step in the activation of fatty acids upon entering a cell?

Conversion to acyl CoA

Which enzyme is responsible for converting fatty acids to their active form CoA derivative in the cytosol?

Fatty acyl CoA synthetase

Why does translocation of fatty acids across the inner mitochondrial membrane occur?

To access the enzymes of beta-oxidation in the mitochondrial matrix

In a-oxidation of fatty acids, what is released one at a time during the process?

Terminal carboxyl as CO2

Which organelle is involved in omega (ω) oxidation of fatty acids?

Endoplasmic reticulum

What is required for the omega oxidation of fatty acids to take place?

Cytochrome p450, NADPH, and molecular O2

Learn about the process and regulators of fatty acid synthesis, the interplay between lipogenesis and lipolysis, different types of FA oxidation, the role of beta oxidation in energy production, and the regulation of FA oxidation. This quiz summarizes key points from a lecture on the metabolism of free fatty acids.

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