Drugs Used in Bladder Disorders

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18 Questions

What is the hallmark symptom of overactive bladder (OAB)?

Urinary urgency

In the female body, why is the bladder smaller compared to males?

Due to its positioning inferior to the uterus

What does urgency urinary incontinence (UUI) refer to?

Urinary leakage associated with urgency

What defines urinary frequency?

Voiding 8 or more times in a 24-hour period

Where is the bladder positioned in males?

Anterior to the rectum

Which organization defines overactive bladder (OAB) as a syndrome?

International Continence Society (ICS)

What is the hallmark symptom of overactive bladder (OAB)?

Urinary urgency

Which type of cholinergic receptors in the bladder is responsible for parasympathetic detrusor contraction?

M3 only

What is the main pharmacologic treatment of choice for overactive bladder (OAB)?

Antimuscarinic agents

Which therapy for overactive bladder involves techniques like bladder training and biofeedback?

Behavioural therapy

What are the major adverse effects that limit the use of antimuscarinic drugs in treating OAB?

Dry mouth and constipation

Which type of receptors in the bladder are not responsible for cardiovascular effects?

Beta 3 receptors

What is the primary mechanism of action of anticholinergics/antimuscarinics in treating bladder disorders?

Antagonism at muscarinic M3 receptors in the bladder detrusor muscle

Which adverse effect is commonly associated with anticholinergic medication use?

Headache

What category of adrenergic receptors are beta 3 receptors classified as?

Beta 3

What is the role of beta 3 receptors in the bladder?

Present in the bladder wall

What is the main indication for using duloxetine in bladder disorders?

Stress incontinence related to physical strain

Which neurotransmitters does duloxetine primarily affect in its mechanism of action?

Serotonin and noradrenaline

Learn about the anatomy of the bladder, a smooth muscular organ that stores urine in the human body. Understand the position and shape of the bladder, as well as its capacity and expansion. Gain insights into drugs used to treat bladder disorders.

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