Questions and Answers
Which condition is characterized by the production of significant fetal hemoglobin (hemoglobin F) well into adulthood?
Hereditary persistence of fetal hemoglobin (HPFH)
What is the result of a point mutation in Hbß, leading to a change from Glu to Val at amino acid 6?
Sickle cell anemia
Which condition is associated with the deletion of five amino acids in the β-chains of the abnormal protein?
Hemoglobin Gun Hill
What is the characteristic feature of Hb Barts and HbH in alpha-thalassemia?
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In uncontrolled diabetes, what can increase more than twice normal, leading to the generation of more HbA1c than normal?
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What is the result of a point mutation in Hbß, leading to a change from Glu to Val at amino acid 6?
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What happens in α thalassemia when one of the 4 gene copies are not expressed?
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What are the subunits that form tetramers in beta thalassemia?
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What is associated with a point mutation in Hbß that leads to the formation of Hb C or Hb E?
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What results from a mutation or incorrect splicing in beta thalassemia?
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