Which sequence in Type I proteins serves as a signal for COPI recognition?
Understand the Problem
The question is asking about the specific sequence in Type I proteins that is recognized by COPI, which pertains to protein transport and cellular signaling. The answer involves understanding protein structure and function.
Answer
KKxx or KxKxx motifs
The final answer is KKxx or KxKxx motifs
Answer for screen readers
The final answer is KKxx or KxKxx motifs
More Information
Type I transmembrane proteins use specific sequences like KKxx or KxKxx at their C-terminal for COPI recognition and subsequent trafficking between the Golgi and the ER.
Tips
Don't confuse COPI recognition with other trafficking signals like KDEL, which is recognized by the KDEL receptor.
Sources
- Molecular Basis for Recognition of Dilysine Trafficking Motifs by COPI - ncbi.nlm.nih.gov
- Rules for the recognition of dilysine retrieval motifs by coatomer - PMC - ncbi.nlm.nih.gov
- Coatomer - an overview | ScienceDirect Topics - sciencedirect.com
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