Which molecule does not normally participate as a reactant in a Friedel-Crafts reaction?

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Understand the Problem

The question is asking which molecule does not typically participate as a reactant in a Friedel-Crafts reaction. This requires knowledge of organic chemistry, specifically about the reactivity of different aromatic compounds.

Answer

Nitrobenzene

The final answer is Nitrobenzene.

Answer for screen readers

The final answer is Nitrobenzene.

More Information

Nitrobenzene is a strong deactivating group due to the electron-withdrawing nitro group, making Friedel-Crafts reactions unfavorable.

Tips

A common mistake is thinking that other less deactivating molecules like chlorobenzene do not participate. Remember, strong deactivators like nitrobenzene are significantly less reactive.

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