Which mechanism illustrates the specificity of G protein coupling in GPCRs? A) Disruption of the ligand binding site. B) Transduction of active conformational changes to G proteins... Which mechanism illustrates the specificity of G protein coupling in GPCRs? A) Disruption of the ligand binding site. B) Transduction of active conformational changes to G proteins. C) Stabilizing both conformations equally. D) Blocking of receptor dimerization.
Understand the Problem
The question is asking which mechanism best represents the specificity of G protein coupling in G-protein-coupled receptors (GPCRs). It provides multiple-choice options that reflect different hypotheses about how GPCRs interact with G proteins.
Answer
Transduction of active conformational changes to G proteins.
The final answer is B) Transduction of active conformational changes to G proteins.
Answer for screen readers
The final answer is B) Transduction of active conformational changes to G proteins.
More Information
The specificity in G-protein coupling with GPCRs is primarily facilitated through the coupling of active receptor conformations that are induced by ligand binding, resulting in the transduction of signals via G-protein recruitment.
Tips
A common mistake is thinking that equal stabilization of conformations means specificity, but specificity often depends on active conformation changes.
Sources
- Common activation mechanism of class A GPCRs - PMC - pmc.ncbi.nlm.nih.gov
- Biochemistry, G Protein Coupled Receptors - StatPearls - NCBI - ncbi.nlm.nih.gov
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