What mechanism is primarily activated by postsynaptic M1Rs?
Understand the Problem
The question is asking about the specific mechanism that is activated by postsynaptic M1 muscarinic receptors (M1Rs). The choices provided relate to different physiological responses that could occur as a result of this receptor activation, and we need to identify which one is primarily associated with M1Rs.
Answer
M1Rs primarily activate intracellular Ca2+ elevation, causing depolarization and increased excitability.
The mechanism primarily activated by postsynaptic M1Rs is elevation of intracellular Ca2+ levels, which leads to slow postsynaptic depolarization and increased neuronal excitability.
Answer for screen readers
The mechanism primarily activated by postsynaptic M1Rs is elevation of intracellular Ca2+ levels, which leads to slow postsynaptic depolarization and increased neuronal excitability.
More Information
The activation of muscarinic M1 receptors (M1Rs) plays a vital role in neural signaling by affecting intracellular calcium levels, thereby depolarizing neurons and increasing their excitability. This is essential for processes like memory and learning.
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