What effect does Ras-GEF have on Ras protein?
Understand the Problem
The question is asking about the specific function of Ras-GEF (Ras Guanine nucleotide Exchange Factor) on the Ras protein, focusing on its role in the activation process involving nucleotide exchange.
Answer
Ras-GEF activates Ras by facilitating GDP-GTP exchange.
Ras-GEF (guanine nucleotide exchange factor) increases the activity of Ras protein by stimulating the release of GDP, which allows GTP to bind to Ras, thus activating it.
Answer for screen readers
Ras-GEF (guanine nucleotide exchange factor) increases the activity of Ras protein by stimulating the release of GDP, which allows GTP to bind to Ras, thus activating it.
More Information
Ras proteins are part of a larger family of small GTPases that regulate various cellular functions. The activity of Ras is crucial in many signaling pathways, and its improper regulation can be linked to diseases like cancer.
Tips
One common mistake is confusing Ras-GEF with Ras-GAP. GEFs activate Ras by promoting GDP-GTP exchange, while GAPs inactivate Ras by accelerating GTP hydrolysis.
Sources
- Ras superfamily GEFs and GAPs: validated and tractable targets for ... - pmc.ncbi.nlm.nih.gov
- Ras GTPase - Wikipedia - en.wikipedia.org
AI-generated content may contain errors. Please verify critical information
